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36455-72-8

中文名稱 ALPHA-玉米赤霉烯醇
英文名稱 ALPHA-ZEARALENOL
CAS 36455-72-8
分子式 C18H24O5
分子量 320.38
MOL 文件 36455-72-8.mol
更新日期 2025/07/29 11:46:20
36455-72-8 結(jié)構(gòu)式 36455-72-8 結(jié)構(gòu)式

基本信息

中文別名
玉米赤霉烯醇Α
Α-玉米赤霉烯醇
ALPHA-玉米赤霉烯醇
Α-玉米赤霉烯醇 標準品
ALFA-ZEARALENOL
Α-玉米赤霉烯醇溶液,100PPM
Α-玉米赤霉烯醇溶液,1000PPM
乙腈中Α-玉米赤霉烯醇溶液,100ΜG/ML
2,4-二羥基- 6-(6Α,10-二羥基反式-)苯甲酸Μ-內(nèi)酯
ALPHA-2,4二羥基- 6 - [10 -二羥基- 1 - 十一碳烯基]苯甲酸酯
英文別名
ZEARALENOL
Α-ZEARALENOL
A-ZEARALENOL
(3S,7R,11E)-
alfa-Zearalenol
ALPHA-ZEARALENOL
Zearalenol, alpha-
trans-α-Zearalenol
α-Zearalenol solution
alpha-Zearalenol solution
所屬類別
分析化學:食品和化妝品標準品

物理化學性質(zhì)

熔點158-161°C
沸點599.0±50.0 °C(Predicted)
密度1.174±0.06 g/cm3(Predicted)
閃點2℃
儲存條件-20°C
溶解度≤20mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
酸度系數(shù)(pKa)7.61±0.60(Predicted)
形態(tài)結(jié)晶固體
顏色White to off-white
穩(wěn)定性吸濕性
主要應用cleaning products
cosmetics
food and beverages
personal care
InChIInChI=1S/C18H24O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h3,7,10-12,14,19-21H,2,4-6,8-9H2,1H3/b7-3+/t12-,14+/m0/s1
InChIKeyFPQFYIAXQDXNOR-QDKLYSGJSA-N
SMILESO1C(=O)C2=C(O)C=C(O)C=C2C=CCCC[C@@H](O)CCC[C@@H]1C |t:12|

安全數(shù)據(jù)

危險性符號(GHS)腐蝕 (GHS05)健康危害 (GHS08)
GHS05,GHS08
警示詞危險
危險品標志Xn,T,F
安全說明36/37-61-16-45-53
危險品運輸編號UN 1648 3 / PGII
WGK Germany3
F8
海關(guān)編碼29322090
存儲類別3 - Flammable liquids
危險性類別Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Flam. Liq. 2
ALPHA-玉米赤霉烯醇價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/12/22HY-N6710ALPHA-玉米赤霉烯醇
α-Zearalenol
36455-72-81 mg1066元
2025/12/22HY-N6710ALPHA-玉米赤霉烯醇
α-Zearalenol
36455-72-85mg2800元
2025/12/22HY-N6710ALPHA-玉米赤霉烯醇
α-Zearalenol
36455-72-810 mM * 1 mLin DMSO3080元

常見問題列表

生物活性
α-Zearalenol 是一種對雌激素受體 (ER) 具有高親和力的霉菌毒素, α-Zearalenol 是 zearalenone (ZEN) 的衍生物,由于其異種雌激素效應可引起動物的生殖障礙。
體外研究

α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) shows the highest RPE (90.5%) at 9.37 μM α-ZOL exposure in MFC-7 cells with an IC 50 of 12.5 μM. α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) induces an increase of cell viability on MCF-7 cells mainly after 72 h of treatment whereas it is slightly cytotoxic on MDA-MB231 cells. α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) increases MCF7 cell population in the S phase and in the G2/M phase, no visible change in cell cycle phases is observed in MDA-MB231 cells. α-Zearalenol (α-zol) (1-10 μM; 24 hours) reduces the expression of TNF-α, α-ZOL combines with β-ZOL shows an antagonistic effect on inflammation for IL-1β and act synergic for IL-8 at high toxin concentrations.

Cell Proliferation Assay

Cell Line: MFC-7 cells
Concentration: 6.25 μM-25 μM
Incubation Time: 24 hours
Result: Observed the highest RPE (90.5%) at 9.37 μM α-ZOL exposure in MFC-7 cells.

Cell Viability Assay

Cell Line: Breast cancer cell lines: MCF-7 and MDA-MB231
Concentration: 0.001 μM, 0.1 μM and 10 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Modified the cell growth in two breast cancer cell lines.

Cell Cycle Analysis

Cell Line: MCF7 cells, MDA-MB231 cells
Concentration: 0.001 μM, 0.1 μM and 10 μM
Incubation Time: 72 hours
Result: Observed an increase of cells in cell cycle in MCF7 cells.

RT-PCR

Cell Line: HepG2 cells
Concentration: 1 μM, 5 μM, 10 μM
Incubation Time: 72 hours
Result: Induced a decrease of the expression of TNF-α, IL-1β and IL-8, that was in most cases statistically significant for the higher doses.
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