364794-79-6
364794-79-6 結(jié)構(gòu)式
基本信息
4-嗎啉甲基苯硼酸頻呢醇酯
4-(4-嗎啉甲基)苯硼酸頻哪酯
4-(4-嗎啉甲基)苯硼酸頻哪醇酯
4-(4-嗎啉基甲基)苯硼酸頻哪醇酯
4-(4-嗎啉甲基)苯硼酸頻哪酯 1G
4-(嗎啉-4-基甲基)苯硼酸頻那醇酯
4-(4-嗎啉甲基)苯硼酸頻哪酯,97%
4-[4-(4,4,5,5-四甲基-1,3,2-二氧硼烷)芐基]嗎啉
4-[4-(4,4,5,5-四甲基-1,3,2-二氧硼基)芐基]嗎啡啉
4-(Morpholinomethyl)phenylboronic acid, pinacol ester
4-(METHYLMORPHOLINO)PHENYLBORONIC ACID, PINACOL ESTER
4-(4-METHYLMORPHOLINE)BENZENEBORONIC ACID, PINACOL ESTER
4-(4-MORPHOLINOMETHYL)PHENYLBORONIC ACID PINACOL ESTER, 97%
4-[(Morpholin-4-yl)methyl]benzeneboronic acid, pinacol ester
4-(4-Morpholinylmethyl)benzeneboronic acid pinacol ester, 97%
4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaboran-2-yl)benzyl]morpholine
4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZYL]MORPHOLINE
4,4,5,5-Tetramethyl-2-[4-(morpholinomethyl)phenyl]-1,3,2-dioxaborolane
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
132833-51-3
73183-34-3
364794-79-6
以4-(4-溴芐基)嗎啉（2.0g，7.8mmol）、聯(lián)硼酸頻哪醇酯（2.4g，9.4mmol）、乙酸鉀（1.1g，12mmol）和1,1'-雙(二苯基膦基)二茂鐵二氯化鈀（660mg，0.1mmol）為原料，在DMF中制備反應(yīng)混合物。將反應(yīng)混合物在80℃下攪拌反應(yīng)過夜。反應(yīng)完成后，將混合物冷卻至室溫，并用乙酸乙酯（100mL）稀釋。所得溶液用飽和氯化鈉水溶液（3×50mL）洗滌。合并有機(jī)相，用無水硫酸鈉干燥，過濾后減壓濃縮，得到粗產(chǎn)物4-(4-嗎啉甲基)苯硼酸頻哪酯（2g，收率84%），無需進(jìn)一步純化即可用于下一步反應(yīng)。
參考文獻(xiàn)：
[1] Patent: WO2009/155565, 2009, A1. Location in patent: Page/Page column 143-144
[2] Patent: WO2013/153357, 2013, A1. Location in patent: Page/Page column 18; 39; 40
[3] Patent: US2015/45354, 2015, A1. Location in patent: Paragraph 0237-0241
[4] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 20, p. 2989 - 2992
[5] Journal of Medicinal Chemistry, 2008, vol. 51, # 2, p. 196 - 218