36913-39-0
中文名稱
1-甲基-4-苯基吡啶離子
英文名稱
MPP+ IODIDE
CAS
36913-39-0
分子式
C12H12IN
分子量
297.135
MOL 文件
36913-39-0.mol
更新日期
2026/07/17 13:02:20
36913-39-0 結(jié)構(gòu)式
基本信息
中文別名
MPP+碘MPP+碘化物
MPTP代謝物
1-甲基-4-苯基吡啶
1-甲基-4-苯基吡啶離子
N-甲基-4-苯基吡啶碘化物
1-甲基-4-苯基吡啶碘化物
1-甲基-4-苯基吡啶鎓碘化物
N-甲基-4-苯基吡啶鎓碘化物
碘化-N-甲基-4-苯基吡啶鹽
英文別名
4-phenylpyridin-1-ium iodide1-methyl-4-phenylpyridin-1-ium
MPP+ IODIDE ISO 9001：2015 REACH
1-methyl-4-phenyl-pyridiniuiodide
N-Methyl-4-phenylpyridinium iodide
1-Methyl-4-phenylpyridin-1-iuM iodide
Pyridinium, 1-methyl-4-phenyl-, iodide
MPP+ iodide,1-Methyl-4-phenylpyridinium iodide
MPP+ IODIDE (ACTIVE METABOLITE OF DOPAMI NERGIC NEUROTOX
所屬類別
有機(jī)原料：烴類鹵化物物理化學(xué)性質(zhì)
熔點(diǎn)166-168 °C
儲(chǔ)存條件desiccated
溶解度0.1 M HCl: soluble
形態(tài)solid
顏色yellow
水溶解性H2O: 10mg/mL, clear
InChIInChI=1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1
InChIKeyRFDFRDXIIKROAI-UHFFFAOYSA-M
SMILESC1(C=C[N+](C)=CC=1)C1=CC=CC=C1.[I-]
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H301+H311+H331-H315-H319-H335
危險(xiǎn)品標(biāo)志T
危險(xiǎn)類別碼23/24/25-36/37/38-25
安全說(shuō)明26-36-45
危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1/PG 2
WGK Germany3
RTECS號(hào)UU6580000
存儲(chǔ)類別6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials
very toxic hazardous materials
危險(xiǎn)性類別Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
1-甲基-4-苯基吡啶鎓碘化物價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-W008719 | 1-甲基-4-苯基吡啶鎓碘化物 MPP+ iodide | 36913-39-0 | 5 mg | 390元 |
| 2026/06/05 | HY-W008719 | 1-甲基-4-苯基吡啶鎓碘化物 MPP+ iodide | 36913-39-0 | 10 mM * 1 mL in DMSO | 429元 |
| 2026/06/05 | HY-W008719 | 1-甲基-4-苯基吡啶鎓碘化物 MPP+ iodide | 36913-39-0 | 10 mg | 555元 |
常見(jiàn)問(wèn)題列表
生物活性
MPP+ iodide 是神經(jīng)毒素 MPTP 的一種有毒代謝物，通過(guò)選擇性破壞黑質(zhì)多巴胺能神經(jīng)元，在動(dòng)物模型中引起帕金森病癥狀。MPP+ iodide 被多巴胺轉(zhuǎn)運(yùn)體吸收進(jìn)入多巴胺能神經(jīng)元，通過(guò)影響呼吸鏈復(fù)合體 I 對(duì)線粒體發(fā)揮神經(jīng)毒性作用。MPP+ iodide 也是 5-羥色胺轉(zhuǎn)運(yùn)體 (SERT) 的高親和力底物。體外研究
MPP+ (1-3 mM; 24 hours) remarkably decreases the viability of cells.
MPP+ also inhibits the activity of nicotinamide adenosine dinucleotide (NADH)-linked respiration in mitochondrial preparations and impairs aerobic glycolysis, leading to the present belief that the inhibition of NADH-linked cell respiration may constitute the final molecular mechanism of MPP+ neurotoxicity.
Cell Viability Assay
| Cell Line: | SH-SY5Y cells |
| Concentration: | 1, 2, 3 mM |
| Incubation Time: | 24 hours |
| Result: | SH-SY5Y cells were treated with MPP+, mimicking the progress of dopaminergic neurons loss in PD; Reduced cell viability in both dose-dependent (1, 2, 3 mM for 24 h) and time dependent (1 mM) manner. |