40592-88-9
中文名稱
TLR4-IN-C34
英文名稱
Isopropyl 2-(acetylamino)-2-deoxy á-D-glucopyranoside 3,4,6-triacetate
CAS
40592-88-9
分子式
C17H27NO9
分子量
389.398
MOL 文件
40592-88-9.mol
更新日期
2023/06/26 10:40:54
40592-88-9 結(jié)構(gòu)式
基本信息
中文別名
ISOPROPYL 2-(ACETYLAMINO)-2-DEOXY á-D-GLUCOPYRANOSIDE 3,4,6-TRIACETATE 英文別名
C34TLR4-C34
TLR4-IN-C34
2-Acetamidopyranoside
Isopropyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranoside
ISOPROPYL 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSIDE 3,4,6-TRIACETATE
Isopropyl 2-(acetylamino)-2-deoxy á-D-glucopyranoside 3,4,6-triacetate
1-Methylethyl 2-(acetylamino)-2-deoxy-a-Dglucopyranoside 3,4,6-triacetate
1-Methylethyl 2-(acetylamino)-2-deoxy-α-D-glucopyranoside 3,4,6-triacetate
Isopropyl 2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-alpha-D-glucopyranoside, Min. 98%
所屬類別
生物化工：抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)519.8±50.0 °C(Predicted)
密度1.21±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C
溶解度H2O: 可溶1mg/mL, 澄清 (加熱)
酸度系數(shù)(pKa)13?+-.0.70(Predicted)
形態(tài)粉末
顏色白色至米色
水溶解性H2O: 1mg/mL, clear (warmed)
InChI1S/C17H27NO9/c1-8(2)24-17-14(18-9(3)19)16(26-12(6)22)15(25-11(5)21)13(27-17)7-23-10(4)20/h8,13-17H,7H2,1-6H3,(H,18,19)/t13-,14-,15-,16-,17+/m1/s1
InChIKeyKMIQMFHPUJUDMC-HHARLNAUSA-N
SMILESN([C@H]1[C@H](O[C@@H]([C@H]([C@@H]1OC(=O)C)OC(=O)C)COC(=O)C)OC(C)C)C(=O)C
安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
防范說(shuō)明P261-P305+P351+P338
WGK Germany3
海關(guān)編碼2938900000
存儲(chǔ)類別11 - Combustible Solids
常見(jiàn)問(wèn)題列表
用途
TLR4-IN-C34是一類新的toll樣受體4 (TLR4)抑制劑，是潛在的抗炎藥物。生物活性
TLR4-IN-C34 是具有口服活性的 TLR4 抑制劑，可改善內(nèi)毒素血癥和壞死性小腸結(jié)腸炎模型的全身炎癥。體內(nèi)研究
TLR4-IN-C34 (C34, 1 mg/kg, orally daily) could attenuate NEC severity and demonstrates a marked preservation of the intestinal mucosa.
| Animal Model: | Experimental NEC induced in 7-8 day old mice. |
| Dosage: | 1 mg/kg. |
| Administration: | Orally every morning. |
| Result: | Attenuated intestinal inflammation. |