42438-89-1
42438-89-1 結(jié)構(gòu)式
基本信息
松茋
松芪
反式-松茋
5-甲氧基-3,4'-二羥基茋
(E)-3-[2-(4-羥基苯基)乙烯基]-5-甲氧基苯酚
3-[(1E)-2-(4-羥基苯基)乙烯基]-5-甲氧基苯酚
42438-89-1
Pinostilbene
Pinostilbene>
trans-Pinostilbene
Pinostilbene hydrate
trans-Pinostilbene hydrate
3-methoxy-4',5-dihydroxy-trans-stilbene
3,4'-Dihydroxy-5-methoxy-trans-stilbene
3-[2-(4-hydroxyphenyl)ethenyl]-5-methoxyphenol
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
Skin Irrit. 2
STOT SE 3
常見(jiàn)問(wèn)題列表
Pinostilbene (0- 40 μM; 24 hours, 48 hours) does not cause significant inhibition on the growth of normal colon cells.
Pinostilbene (20 μM, 40 μM; 24 hours, 48 hours) causes a significant and dose-dependent increase in the percentage of cells in S phase in both HCT116 and HT29 cells compared to the control cells.
Pinostilbene at μM also induces a modest increase of cell population in G2/M phase in HT29 cells.
Pinostilbene(20 μM, 40 μM; 24 hours, 48 hours) modulates expression of key signaling proteins related to cell proliferation and apoptosis.
Pinostilbene also acts as a resveratrol methylated derivative and displays protective effects against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells.
Cell Viability Assay
| Cell Line: | HCT116 cells, HT29 cells |
| Concentration: | 24 hours, 48 hours |
| Incubation Time: | 0-100 μM |
| Result: | Inhibited the growth of two human colon cancer cells. |
Apoptosis Analysis
| Cell Line: | HCT116 cells, HT29 cells |
| Concentration: | 20 μM, 40 μM |
| Incubation Time: | 24 hours, 48 hours |
| Result: | Caused a significant and dose-dependent increase in the percentage of cells in S phase. |
Cell Viability Assay
| Cell Line: | HCT116 cells |
| Concentration: | 20 μM,40 μM |
| Incubation Time: | 24 hours, 48 hours |
| Result: | Significantly increased the expression levels of p53, Bax, cleaved caspase-3, cleaved PARP and p21 Cip1/Waf1 , while decreased the expression levels of cyclin E and p-Rb. |