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42464-96-0

中文名稱 5-氨基-1-甲基喹啉-1-鎓碘化物
英文名稱 NNMTi
CAS 42464-96-0
更新日期 2026/07/20 20:57:37
分子式 C10H11N2.I
分子量 286.11
MOL 文件 42464-96-0.mol
42464-96-0 結(jié)構式 42464-96-0 結(jié)構式

基本信息

中文別名
5-氨基-1甲基喹啉碘化物
5-氨基-1-甲基喹啉碘代物
5-氨基-1-甲基喹啉-1-碘化物
英文別名
NNMTi
5-amino-1MQ
5-Amino-1methylquinolinium iodide
5-amino-1-methylquinolin-1-ium iodide
所屬類別
醫(yī)藥中間體:喹啉類化合物

物理化學性質(zhì)

熔點213-214 °C
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
形態(tài)Solid
顏色Brown to reddish brown
InChI1S/C10H10N2.HI/c1-12-7-3-4-8-9(11)5-2-6-10(8)12;/h2-7,11H,1H3;1H
InChIKeyJPEZFBFIRRAFNR-UHFFFAOYSA-N
SMILESC[N+]1=CC=CC2=C(C=CC=C12)N.[I-]

安全數(shù)據(jù)

危險性符號(GHS)有害 (GHS07)
GHS07
警示詞警告
危險性描述H302-H315-H319-H335
WGK GermanyWGK 3
存儲類別11 - Combustible Solids

上下游產(chǎn)品信息

5-氨基-1-甲基喹啉-1-鎓碘化物價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2026/06/05HY-1310425-氨基-1-甲基喹啉-1-鎓碘化物
NNMTi
42464-96-05mg600元
2026/06/05HY-1310425-氨基-1-甲基喹啉-1-鎓碘化物
NNMTi
42464-96-010mM * 1mLin DMSO660元
2026/06/05HY-1310425-氨基-1-甲基喹啉-1-鎓碘化物
NNMTi
42464-96-010 mg860元

常見問題列表

生物活性
NNMTi 是一種有效的煙酰胺 N -甲基轉(zhuǎn)移酶 (NNMT) 的抑制劑 (IC50=1.2 μM),可選擇性地結(jié)合 NNMT 底物結(jié)合位點殘基。NNMTi 能促進體外成肌細胞分化,增強老年小鼠肌肉干細胞融合和再生能力。
體外研究

NNMTi (10-30 μM; 96 hours) produces a concentration-related increase in myoblast differentiation on C2C12 myoblast differentiation. 30 μM NNMTi results in 18% MHC-positive myotube nuclei, representing a 45% increase in the extent of myoblast differentiation compared to untreated differentiating myoblasts (12% MHC-positive myotube nuclei).

體內(nèi)研究

NNMTi (subcutaneous (SC) injection; 5 mg/kg and 10 mg/kg; 2 weeks (1 week pre-injury and 1 week post-injury)) has an effect on muscle regeneration after injury, it results in 60% and 75% higher incidence of proliferating/active muSCs at 5 mg/kg and 10 mg/kg, respectively. The relative numbers of fibers with an EdU + myonucleus increased 40% and 48% with NNMTi treatment at 5 mg/kg and 10 mg/kg, respectively. The odds ratio of fused myonuclei for control are 0.58 and 0.53 times the odds at the low and high NNMTi dose, respectively.NNMTi (subcutaneous injection; 10 mg/kg; 1 week) produces no systemic toxicity in mice, the levels of the glucose, cholesterol, plasma proteins, and electrolytes between control and NNMTi-treated samples show no difference in mice. 1-week post-injury daily repeat-dosing of NNMTi is well tolerated with no untoward systemic toxicity or behavioral implications in aged mice.

"42464-96-0" 相關產(chǎn)品信息
7681-82-5 12027-06-4 42464-96-0 69235-50-3
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