428861-91-0
428861-91-0 結構式
基本信息
中文別名
化合物 T12509 英文別名
PNU-176798Acetamide, N-[[(5S)-3-[4-(5-cyano-2-thiazolyl)-3-fluorophenyl]-2-oxo-5-oxazolidinyl]methyl]-
常見問題列表
生物活性
PNU-176798 是一種抗菌劑，能夠作用于大多數革蘭氏陽性菌和厭氧菌的蛋白合成。靶點
Bacterial
體外研究
PNU-176798 is an antimicrobial agent, with a minimum inhibitory concentration (MIC) of 1.4 μM for E. coli . PNU-176798 inhibits fMet-tRNA binding to the 70S ribosomes, with an IC 50 of 32 μM. PNU-176798 also blocks translation, 70S initiation with IC 50 s of 0.53, and 32 μM, respectively. PNU-176798 inhibits peptidyl transferase (IC 50 , 40 μM), and the inhibition is more pronounced in the presence of elongation factor P (EF-P). PNU-176798 markedly inhibits the EF-G-mediated translocation of fMet-tRNA (IC 50 , 8 μM).