428861-91-0
428861-91-0 結(jié)構(gòu)式
基本信息
中文別名
化合物 T12509 英文別名
PNU-176798Acetamide, N-[[(5S)-3-[4-(5-cyano-2-thiazolyl)-3-fluorophenyl]-2-oxo-5-oxazolidinyl]methyl]-
物理化學(xué)性質(zhì)
密度1.49±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)15.53±0.46(Predicted)
常見(jiàn)問(wèn)題列表
生物活性
PNU-176798 是一種抗菌劑，能夠作用于大多數(shù)革蘭氏陽(yáng)性菌和厭氧菌的蛋白合成。靶點(diǎn)
Bacterial
體外研究
PNU-176798 is an antimicrobial agent, with a minimum inhibitory concentration (MIC) of 1.4 μM for E. coli . PNU-176798 inhibits fMet-tRNA binding to the 70S ribosomes, with an IC 50 of 32 μM. PNU-176798 also blocks translation, 70S initiation with IC 50 s of 0.53, and 32 μM, respectively. PNU-176798 inhibits peptidyl transferase (IC 50 , 40 μM), and the inhibition is more pronounced in the presence of elongation factor P (EF-P). PNU-176798 markedly inhibits the EF-G-mediated translocation of fMet-tRNA (IC 50 , 8 μM).