456-12-2
中文名稱
印枳堿
英文名稱
Aegelin
CAS
456-12-2
分子式
C18H19NO3
分子量
297.35
MOL 文件
456-12-2.mol
更新日期
2026/02/12 14:46:44
456-12-2 結(jié)構(gòu)式
基本信息
中文別名
印枳堿N-[2-羥基-2-(4-甲氧基苯基)乙基]肉桂酰胺
英文別名
AegelinAegeline
N-CinnaMoyl-β-hydroxy-4-Methoxyphenyl-aethylaMin
N-Cinnamoyl-β-hydroxy-4-methoxyphenyl-aethylamin
N-(2-Hydroxy-2-(4-Methoxyphenyl)ethyl)cinnaMaMide
(E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]cinnamamide
(E)-N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylprop-2-enamide
Aegeline,N-[2-hydroxy-2(4-Methoxyphenyl) ethyl]-3-phenyl-2-propenaMide
2-Propenamide, N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-, (2E)-
AegelineQ: What is Aegeline Q: What is the CAS Number of Aegeline Q: What is the storage condition of Aegeline Q: What are the applications of Aegeline
所屬類別
醫(yī)藥中間體：原料藥中間體物理化學性質(zhì)
熔點178-179℃
沸點567.7±50.0 °C(Predicted)
密度1.178±0.06 g/cm3(Predicted)
儲存條件under inert gas (nitrogen or Argon) at 2-8°C
酸度系數(shù)(pKa)13.70±0.20(Predicted)
形態(tài)粉末晶體
顏色白色至淺黃色
主要應用pharmaceutical (small molecule)
InChI1S/C18H19NO3/c1-22-16-10-8-15(9-11-16)17(20)13-19-18(21)12-7-14-5-3-2-4-6-14/h2-12,17,20H,13H2,1H3,(H,19,21)/b12-7+
InChIKeyQRFDENJATPJOKG-KPKJPENVSA-N
SMILESN(CC(O)c2ccc(cc2)OC)C(=O)\C=C\c1ccccc1
安全數(shù)據(jù)
警示詞警告
危險性描述H302
WGK GermanyWGK 3
海關(guān)編碼2924.29.7790
存儲類別11 - Combustible Solids
危險性類別Acute Tox. 4 Oral
常見問題列表
用途
印枳堿是一種化合物，可以從生長在印度的Aegle marmelos樹的葉子中提取。研究發(fā)現(xiàn)這種樹的精油對21種細菌有效。印枳堿也有抗肥胖作用。
用途
印枳堿為芳香類衍生物，其可用作醫(yī)藥合成中間體。生物活性
Aegeline 是一種主要生物堿，模擬酵母 SNARE 蛋白 Sec22p 抑制酵母 α-突觸核蛋白和 Bax 毒性。Aegeline 恢復 αsyn 或 Bax 抑制的酵母細胞生長。體外研究
Aegeline also prevents growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein or
Bax-expressing cells.
Aegeline shows weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin.