480-66-0
中文名稱
2,4,6-三羥基苯乙酮
英文名稱
2',4',6'-Trihydroxyacetophenone monohydrate
CAS
480-66-0
EINECS 編號
207-556-5
分子式
C8H8O4
MDL 編號
MFCD00002287
分子量
168.15
MOL 文件
480-66-0.mol
更新日期
2026/05/23 10:49:59
480-66-0 結(jié)構(gòu)式
基本信息
中文別名
2,4,6-三羥基苯乙酮，水合2,4,6-三羥基苯乙酮
2',4',6'-三羥基苯乙酮一水合物
2',4',6'-三羥基苯乙酮水合物
2',4',6'-三羥基苯乙酮 水合物, 98+%
英文別名
1-(2,4,6-TRIHYDROXYPHENYL)-ETHANONE2',4',6'-TRIHYDROXYACETOPHENONE
PHLOROACETOPHENONE
1-(2,4,6-trihydroxyphenyl)-ethanon
2,4,6-Trihydroxyacetophenon
2,4,6-TrihydroxyacetophenonMonohydrat
2,4,6-trihyroxyacetophenone
2-Acetyl-1,3,5-trihydroxybenzene
2-Acetylphloroglucin
Acetophenone, 2',4',6'-trihydroxy-
Acetophenone,2’,4’,6’-trihydroxy-
Acetophloroglucine
Acetylphloroglucinol
Ethanone,1-(2,4,6-trihydroxyphenyl)-
Phloracetophene
Phloracetophenone
Phloroacetophenonehydrate
2,4,6-TRIHYDROXYACETOPHENONE(PHLOROACETOPHENONE)
2,4,6-Trihydroxyaetcophenone
2,4,6-TRIHYDROXYACETOPHENONE MONOHYDRATE, PGE. WITH 10X10 MG
所屬類別
化學(xué)試劑：芳香酮物理化學(xué)性質(zhì)
外觀性狀微黃色結(jié)晶。熔點(diǎn)217-219℃。
熔點(diǎn)219-221 °C(lit.)
沸點(diǎn)257.07°C (rough estimate)
密度1.3037 (rough estimate)
折射率1.5090 (estimate)
儲存條件Store below +30°C.
溶解度可溶于DMSO（少量）、乙醇（少量）、甲醇（少量）、水（非常少量，
酸度系數(shù)(pKa)7.76±0.23(Predicted)
形態(tài)粉末
顏色light yellow
水溶解性易溶于水。
BRN1911197
穩(wěn)定性Stable under recommended storage conditions., Stable Under Recommended Storage C
InChI1S/C8H8O4/c1-4(9)8-6(11)2-5(10)3-7(8)12/h2-3,10-12H,1H3
InChIKeyXLEYFDVVXLMULC-UHFFFAOYSA-N
LogP1.472 (est)
CAS 數(shù)據(jù)庫480-66-0(CAS DataBase Reference)
NIST化學(xué)物質(zhì)信息Ethanone, 1-(2,4,6-trihydroxyphenyl)-(480-66-0)
EPA化學(xué)物質(zhì)信息Ethanone, 1-(2,4,6-trihydroxyphenyl)- (480-66-0)
安全數(shù)據(jù)
警示詞警告
危險性描述H303-H315-H319-H335
危險品標(biāo)志Xi
危險類別碼R36/37/38
安全說明S26-S36-S24/25
WGK Germany3
RTECS號AN0528000
Hazard NoteIrritant
TSCAYes
危險等級IRRITANT
海關(guān)編碼29145000
存儲類別11 - Combustible Solids
危險性類別Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Skin Irrit. 2
STOT SE 3
2,4,6-三羥基苯乙酮價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/03/03 | L04156 | 2',4',6'-三羥基苯乙酮 水合物, 98+% 2',4',6'-Trihydroxyacetophenone hydrate, 98+% | 480-66-0 | 5g | 325元 |
| 2026/03/03 | 13979 | 2',4',6'-三羥基苯乙酮 水合物 2',4',6'-Trihydroxyacetophenone, 98%, Thermo Scientific Chemicals | 480-66-0 | 25g | 1843元 |
| 2026/03/03 | S4784 | 2,4,6-三羥基苯乙酮 Phloracetophenone | 480-66-0 | 25mg | 794.81元 |
常見問題列表
生物活性
Phloracetophenone (2,4,6-trihydroxyacetophenone) 是多葉姜黃 (Curcuma comosa Roxb) 中苯乙酮糖苷的糖苷配基部分，具有降低膽固醇作用，能夠增強(qiáng)膽固醇 7α-羥化酶 (CYP7A1) 的活性；Phloracetophenone 通過 Mrp2 刺激膽汁分泌。靶點(diǎn)
Cholesterol 7α-hydroxylase, Mrp2
體外研究
Phloracetophenone (2,4,6-trihydroxyacetophenone) is a cholesterol-lowering agent, enhances cholesterol 7α-hydroxylase (CYP7A1) activity, and elevates CYP7A1 mRNA level.
Phloracetophenone (1, 2, and 4 μmol/min) immediately and dose-dependently increases bile acid-independent bile flow in the isolated perfused rat liver.
體內(nèi)研究
Phloracetophenone (2,4,6-trihydroxyacetophenone; 125 or 250 μmol/kg, intraduodenal injection) shows choleretic activity requiring multidrug resistance protein-2 (Mrp2) in rats. Phloracetophenone (40 μmol/min) partially prevents the E2-17G induced cholestasis.