496946-78-2
496946-78-2 結(jié)構(gòu)式
基本信息
5-三氟甲基-1H-吲哚-2-羧酸
5-(三氟甲基)-1H-2-吲哚甲酸
5-Trifluoromethyl-1H-indole-2-carboxylicaci
5-(TRIFLUOROMETHYL)INDOLE-2-CARBOXYLIC ACID
5-TRIFLUOROMETHYL-1H-INDOLE-2-CARBOXYLIC ACID
5-trifluoroMethyl-1H-indoleI-2-carboxylic acid
5-(Trifluoromethyl)indole-2-carboxylic acid ,95%
1H-Indole-2-carboxylic acid, 5-(trifluoromethyl)-
5-TRIFLUOROMETHYL-1H-INDOLE-2-CARBOXYLIC ACID ISO 9001：2015 REACH
物理化學(xué)性質(zhì)
制備方法
127-17-3
163444-17-5
496946-78-2
以丙酮酸和4-氨基-3-碘三氟甲苯為原料合成5-三氟甲基吲哚-2-羧酸的一般步驟：將2.28 g 2-碘-4-三氟甲基苯胺、2.10 g丙酮酸、2.67 g DAI3CO、89 mg乙酸鈀(II)和25 mL DMF的混合物在100°C下攪拌24小時(shí)，反應(yīng)在氮?dú)夥諊羞M(jìn)行。反應(yīng)完成后，將反應(yīng)混合物冷卻至室溫，加入25 mL乙酸乙酯和50 mL 5M鹽酸，用乙酸乙酯萃取3次。合并有機(jī)層，依次用水和飽和食鹽水洗滌，用無水硫酸鎂干燥，減壓濃縮除去溶劑。殘余物用氯仿洗滌，得到1.15 g 5-三氟甲基吲哚-2-羧酸（以下簡(jiǎn)稱“化合物7”）。1H-NMR (DMSO-d6) δ: 13.24 (br s, 1H), 12.20 (br s, 1H), 8.08 (s, 1H), 7.60 (d, 1H, J = 8.8 Hz), 7.51 (dd, 1H, J = 8.8, 1.6 Hz), 7.24 (d, 1H, J = 1.6 Hz)。
參考文獻(xiàn)：
[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 9, p. 2722 - 2725
[2] Patent: WO2015/49616, 2015, A1. Location in patent: Page/Page column 66; 67
[3] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 24, p. 4385 - 4388
[4] Patent: US2007/88071, 2007, A1. Location in patent: Page/Page column 16
[5] Patent: US2015/289512, 2015, A1. Location in patent: Paragraph 1210; 1211