497061-48-0
497061-48-0 結(jié)構(gòu)式
基本信息
DC_AC50 (DC-AC50
DC_AC50 >=98% (HPLC)
3-amino-N-(2-bromo-4,6-difluorophenyl)-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide
5H-Cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide, 3-amino-N-(2-bromo-4,6-difluorophenyl)-6,7-dihydro-
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
Skin Irrit. 2
STOT SE 3
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-107636 | DC_AC50 | 497061-48-0 | 1 mg | 386元 |
| 2026/06/05 | HY-107636 | DC_AC50 DC_AC50 | 497061-48-0 | 5mg | 850元 |
| 2026/06/05 | HY-107636 | DC_AC50 | 497061-48-0 | 10 mM * 1 mLin DMSO | 935元 |
常見問題列表
DC_AC50 exhibits IC
50
values of 9.88 μM, 12.57 μM, 5.96 μM and 6.68 μM in Canine Abrams, Canine D1, human HOS and human MG63) cells, respectively.
DC_AC50 (0-10 μM)-treated cells are significantly less mitotically active, as demonstrated by decreased expression of phospho-histone H3 and cell cycle analysis.
DC_AC50 (10 μM) potentiates carboplatin-induced apoptosis in OSA cells and decreasesclonogenic survival.
DC_AC50 induces cell cycle arrest at both the 3 and 10 μM doses and DC_AC50 induces increase S phase cells dose-independently.
DC_AC50 (3 μM) inhibits the migration and of canine and human OSA cells.
DC_AC50 (2.5-10 μM) is highly efficient at inhibiting cancer cell proliferation (human lung cancer H1299 cells, leukaemia cancer K562 cells, breast cancer MDA-MB-231 cells and head and neck cancer 212LN cells) in a dose-dependent manner. DC_AC50 fails to exhibit any notable inhibition of the cell proliferation of human normal epithelial lung BEAS-2B cells or breast MCF-10A cells as control cells.
Cell Viability Assay
| Cell Line: | Canine OSA (Abrams, D1 and human OSA (HOS, MG63) cells. |
| Concentration: | 0-10 μM. |
| Incubation Time: | 72 h. |
| Result: | Dose-dependently decreased viability of OSA cells. |
Apoptosis Analysis
| Cell Line: | Abrams and HOS cells. |
| Concentration: | 1, 3 and 10 μM (10 μM Carboplatin). |
| Incubation Time: | 24 h. |
| Result: | Potentiated carboplatin-induced apoptosis. |