49745-95-1
49745-95-1 結(jié)構(gòu)式
基本信息
4-[2-[3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]AMINOETHYL]-1,2-BENZENEDIOL HYDROCHLORIDE
4-[2-[4-(4-HYDROXYPHENYL)BUTAN-2-YLAMINO]ETHYL]BENZENE-1,2-DIOL
DOBUTAMINE HCL
4-[2-[[3-(p-hydroxyphenyl)-1-methylpropyl]amino]ethyl]pyrocatechol hydrochloride
Inotrex
1,2-Benzenediol, 4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-, hydrochloride
DL-Dobutamine hydrochloride
Dobutrex
NSC 299583
(±)-3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenethylamine hydrochloride
(+)-p-[2-[3-(p-Hydroxyphenyl)-1-methylpropylamino]ethyl]pyrocatechol hydrochloride
46236
Dobux
Dopmin
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Repr. 2
常見問題列表
Dobutamine hydrochloride has a rapid onset of action and a short half-life .
Dobutamine hydrochloride (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice.
Dobutamine hydrochloride results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice.
Low doses of Dobutamine hydrochloride significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice.
Dobutamine hydrochloride increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost.
Dobutamine hydrochloride increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation.
| Animal Model: | Tgαq*44 mice (heart failure models) |
| Dosage: | 0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose |
| Administration: | Intraperitoneal injection |
| Result: | Induced different response in cardiac function on a low and high dose in mice with with heart failure. |