514-07-8
中文名稱(chēng)
蒲公英萜酮
英文名稱(chēng)
(4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one
CAS
514-07-8
分子式
C30H48O
分子量
424.7
MOL 文件
514-07-8.mol
更新日期
2023/11/22 17:16:08
514-07-8 結(jié)構(gòu)式
基本信息
中文別名
蒲公英賽酮蒲公英萜酮
蒲公英萜酮, 來(lái)源于南沙參
英文別名
TarxeroneTaraxeron
Taraxera-14-ene-3-one
D-Friedoolean-14-en-3-one
27-Norolean-14-en-3-one,13-methyl-, (13a)-
27-Norolean-14-en-3-one, 13-methyl-, (13α)-
Taraxerone, 98%, from Adenophora tetraphylla(Thunb.)Fisch
(4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one
所屬類(lèi)別
天然產(chǎn)物：萜類(lèi)物理化學(xué)性質(zhì)
外觀(guān)性狀白色結(jié)晶粉末，可溶于甲醇、乙醇、DMSO等有機(jī)溶劑，來(lái)源于淡竹葉、蒲公英。
熔點(diǎn)241-243 °C
沸點(diǎn)488.3±44.0 °C(Predicted)
密度1.01±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
形態(tài)Solid
顏色White to off-white
LogP10.480 (est)
常見(jiàn)問(wèn)題列表
生物活性
Taraxerone 是從景天中分離出來(lái)的。Taraxerone 增強(qiáng)乙醇脫氫酶 (ADH) 和乙醛脫氫酶 (ALDH) 活性，EC50 值分別為 512.42 μM 和 500.16 μM。靶點(diǎn)
EC50: 512.42 μM (ADH); 500.16 μM (ALDH)
體內(nèi)研究
Taraxerone significantly lowers the plasma alcohol and acetaldehyde concentrations in mice. Compare to the control group, the ADH and ALDH expressions in the liver tissues are abruptly increased in the taraxerone-treated groups after ethanol exposure. Taraxerone prevents catalase, superoxide dismutase, and reduces glutathione concentrations from the decrease induced by ethanol administration.