516-55-2
中文名稱
別孕烯醇酮
英文名稱
ALLOPREGNANOLONE
CAS
516-55-2
EINECS 編號(hào)
208-224-2
分子式
C21H34O2
MDL 編號(hào)
MFCD00064935
分子量
318.49
MOL 文件
516-55-2.mol
更新日期
2026/05/25 17:23:35
516-55-2 結(jié)構(gòu)式
基本信息
中文別名
別孕烷醇酮異孕烷醇酮
別孕烯醇酮 別孕酮中間體
5ALPHA-孕甾-3BETA-醇-20-酮
5ALPHA-孕甾-3BETA-醇--20-酮,四氫孕酮非標(biāo)
5ALPHA-孕甾-3BETA-醇-20-酮,四氫孕酮(17A,21,21,21-D4,97%+)96%PURE
1-[(8R,9S,10S,13S,14S,17S)-3-羥基-10,13-二甲基-2,3,4,5,6,7,8,9,11,12,14,15,16,17-十四氫-1H-環(huán)戊烷并[A]菲-17-基]乙酮
英文別名
ALLOPREGNANOLONE 所屬類別
有機(jī)原料：酮類化合物物理化學(xué)性質(zhì)
熔點(diǎn)200℃
比旋光度D27 +91.2° (c = 0.4 in ethanol)
沸點(diǎn)431.2±18.0 °C(Predicted)
密度1.1 g/cm3
儲(chǔ)存條件Refrigerator
溶解度可溶于氯仿（少許）、甲醇（少許）
酸度系數(shù)(pKa)15.12±0.70(Predicted)
形態(tài)固體
顏色白色至灰白色
CAS 數(shù)據(jù)庫(kù)516-55-2(CAS DataBase Reference)
常見(jiàn)問(wèn)題列表
用途
異丙孕酮用于制備抗菌和抗白血病類固醇。中間體。生物活性
Alloepipregnanolone 是一種具有催眠和鎮(zhèn)靜作用的孕酮，它能干擾乙醇抗焦慮作用的快速耐受。靶點(diǎn)
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Human Endogenous Metabolite
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體內(nèi)研究
On day 2, pretreatment with a 0.20 mg/kg dose of Alloepipregnanolone blocks the development of rapid tolerance to the anxiolytic effect of ethanol. However, there is a significant decrease in the anxiolytic effect in the control groups that received ethanol on both days (EE), suggesting that the 1.5 g/kg dose of ethanol results in rapid tolerance. The post hoc analysis confirms that the 0.20 mg/kg pretreatment with Alloepipregnanolone blocks the rapid tolerance compared to the control groups, although the 0.10 mg/kg dose only partially blocks the development of such tolerance. However, the 0.05 mg/kg dose has no effect on the development of rapid tolerance to ethanol.