52-52-8
中文名稱
環(huán)亮氨酸
英文名稱
Cycloleucine
CAS
52-52-8
EINECS 編號(hào)
200-144-6
分子式
C6H11NO2
MDL 編號(hào)
MFCD00001381
分子量
129.16
MOL 文件
52-52-8.mol
更新日期
2025/11/30 10:40:28
52-52-8 結(jié)構(gòu)式
基本信息
中文別名
環(huán)亮氨酸1-氨基-1-環(huán)戊烷羧酸
環(huán)白氨酸
1-氨基環(huán)戊烷甲酸
1-氨基-1-環(huán)戊羧酸
1-氨基環(huán)戊烷羧酸
氨基環(huán)戊甲酸
1-氨基環(huán)戊烷甲酸, 97+%
英文別名
1-AMINO-1-CARBOXYCYCLOPENTANE1-AMINO-1-CYCLOPENTANECARBOXYLIC ACID
1-AMINOCYCLOPENTANE-1-CARBOXYLIC ACID
1-AMINOCYCLOPENTANECARBOXYLIC ACID
ACPC
CYCLEU
CYCLOLEUCINE
H-AC5C-OH
H-CLE-OH
H-NH(1)CPEN-OH
RARECHEM AK HD C019
TIMTEC-BB SBB004230
1-amino-cyclopentanecarboxylicaci
Amino-1-cyclopentanecarboxylic acid
CB 1639
cb1639
Cycloleucin
Cyclopentanecarboxylic Acid, 1-amino-, L-
Cyclopentanecarboxylic acid, L-amino
l-cyclopentanecarboxylicaci
所屬類別
生物化工：常見(jiàn)氨基酸及蛋白質(zhì)類物理化學(xué)性質(zhì)
熔點(diǎn)320 °C (dec.)(lit.)
沸點(diǎn)239.22°C (rough estimate)
密度1.1426 (rough estimate)
折射率1.4827 (estimate)
儲(chǔ)存條件Store at RT.
溶解度DMSO: < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)
酸度系數(shù)(pKa)2.38±0.20(Predicted)
形態(tài)結(jié)晶薄片或粉末
顏色白色至米色
水溶解性5 g/100 mL
Merck14,2734
BRN636626
主要應(yīng)用peptide synthesis
InChI1S/C6H11NO2/c7-6(5(8)9)3-1-2-4-6/h1-4,7H2,(H,8,9)
InChIKeyNILQLFBWTXNUOE-UHFFFAOYSA-N
SMILESNC1(CCCC1)C(O)=O
CAS 數(shù)據(jù)庫(kù)52-52-8(CAS DataBase Reference)
NIST化學(xué)物質(zhì)信息Cyclopentanecarboxylic acid, 1-amino-(52-52-8)
EPA化學(xué)物質(zhì)信息Cyclopentanecarboxylic acid, 1-amino- (52-52-8)
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H301
防范說(shuō)明P301+P310+P330
危險(xiǎn)品標(biāo)志Xn,Xi
危險(xiǎn)類別碼R22
安全說(shuō)明S22-S24/25
危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1/PG 3
WGK Germany3
RTECS號(hào)GY2625000
TSCAYes
危險(xiǎn)等級(jí)6.1
包裝類別III
海關(guān)編碼29224999
存儲(chǔ)類別6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
toxic compounds or compounds which causing chronic effects
危險(xiǎn)性類別Acute Tox. 3 Oral
毒害物質(zhì)數(shù)據(jù)52-52-8(Hazardous Substances Data)
毒性LD50 oral in rat: 290mg/kg
52-52-8(安全特性,毒性,儲(chǔ)運(yùn))
儲(chǔ)運(yùn)特性
庫(kù)房通風(fēng)低溫干燥毒性分級(jí)
高毒急性毒性
口服-大鼠LD50: 290 毫克/公斤; 口服-小鼠LD50: 119 毫克/公斤可燃性危險(xiǎn)特性
可燃;燃燒產(chǎn)生有毒氮氧化物煙霧類別
有毒物品滅火劑
干粉、泡沫、砂土、二氧化碳, 霧狀水環(huán)亮氨酸價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/03/03 | B22179 | 1-氨基環(huán)戊烷甲酸, 97+% 1-Aminocyclopentanecarboxylic acid, 97+% | 52-52-8 | 1g | 207元 |
| 2026/03/03 | 10347 | 1-氨基環(huán)戊烷甲酸 1-Amino-1-cyclopentanecarboxylic acid, 97%, Thermo Scientific Chemicals | 52-52-8 | 5g | 593元 |
| 2025/12/22 | HY-30008 | 環(huán)亮氨酸 Cycloleucine | 52-52-8 | 5 mg | 164元 |
常見(jiàn)問(wèn)題列表
生物活性
Cycloleucine 是一種 S-腺苷甲硫氨酸介導(dǎo)的甲基化的特異性抑制劑。Cycloleucine 是 NMDA 受體甘氨酸變構(gòu)位點(diǎn)的拮抗劑，Ki 值為 600 μM。Cycloleucine 在體外也是 ATP：L-蛋氨酸-S-腺苷基轉(zhuǎn)移酶的競(jìng)爭(zhēng)性抑制劑。Cycloleucine 具有抗焦慮和抑制細(xì)胞作用。靶點(diǎn)
Ki: 600 μM (NMDA)
體外研究
Cycloleucine (4-40 mM; 3 h) blocks internal methylation of viral RNA in B77 transformed chick embryo fibroblasts.
Cycloleucine (40 mM; 24 h) blocks the formation of both m
6
A and the penultimate G
m
in B77 38S RNA subunits by greater than 90%.
Cytostatic (10 μg/mL) inhibits the viability human KB and mouse L1210s leukemia cell lines.
體內(nèi)研究
Cycloleucine (0.5-4 μg; intracerebroventrical injection) increases time spent in open arms, open arm entries, and extreme arrivals in rats.
| Animal Model: | Male rats bilaterally cannulated into the nucleus accumbens septi (NAS) |
| Dosage: | 1 μL of 0.5, 1.0, 2.0, 4 μg/μL |
| Administration: | Intracerebroventrical injection |
| Result: |
Increased time spent in the open arms and extreme arrivals at all doses.
Increased open arm entries at the dose of 4 μg. |