52029-86-4

中文名稱 STO-609

英文名稱 7-OXO-7H-BENZIMIDAZO[2,1-A]BENZ[DE]ISOQUINOLINE-3-CARBOXYLIC ACID ACETATE

CAS 52029-86-4

分子式 C19H10N2O3

分子量 314.29

MOL 文件 52029-86-4.mol

更新日期 2026/06/08 11:17:14

52029-86-4 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 應(yīng)用領(lǐng)域安全數(shù)據(jù) STO-609價(jià)格(試劑級(jí)) 常見問(wèn)題列表

基本信息

中文別名

化合物STO609

英文別名

STO-609
STO-609, >98%
STO609
STO 609
STO-609 ACETATE
STO-609 free base
STO-609 ACETIC ACID
STO-609 - CAS 52029-86-4 - Calbiochem
7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid
7H-Benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, 7-oxo-
7-OXO-7H-BENZIMIDAZO[2,1-A]BENZ[DE]ISOQUINOLINE-3-CARBOXYLIC ACID ACETATE

所屬類別

生物化工：激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

熔點(diǎn)>300 °C

沸點(diǎn)716.9±62.0 °C(Predicted)

密度1.54±0.1 g/cm3(Predicted)

儲(chǔ)存條件Sealed in dry,2-8°C

溶解度DMSO: 15 mg/mL at ≥60 °C

酸度系數(shù)(pKa)2.65±0.20(Predicted)

形態(tài)solid

顏色Light yellow to yellow

InChI1S/C19H10N2O3/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18/h1-9H,(H,23,24)

InChIKeyMYKOWOGZBMOVBJ-UHFFFAOYSA-N

應(yīng)用領(lǐng)域

用途1

一種特異性的CaM-KK的抑制劑，抑制CaM-KKα和CaM-KKβ，Ki值分別為80ng/ml和15ng/ml，并抑制其自身磷酸化活性。STO-609 is a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. STO-609 inhibits the activities of recombinant CaM-KK alpha and CaM-KK beta isoforms, with K(i) values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation activities. STO-609 is highly selective for CaM-KK without any significant effect on the downstream CaM kinases (CaM-KI and -IV), and the IC(50) value of the compound against CaM-KII is approximately 10 microg/ml. STO-609 is a selective and cell-permeable inhibitor of CaM-KK and that it may be a useful tool for evaluating the physiological significance of the CaM-KK-mediated pathway in vivo as well as in vitro.

安全數(shù)據(jù)

安全說(shuō)明22-24/25

WGK Germany3

存儲(chǔ)類別11 - Combustible Solids

STO-609價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-19805	STO-609 STO-609	52029-86-4	1mg	400元
2026/06/05	HY-19805	STO-609 STO-609	52029-86-4	5mg	800元
2026/06/05	HY-19805	STO-609 STO-609	52029-86-4	10mg	1280元

常見問(wèn)題列表

生物活性

STO-609 是特異性的CaM-KK的抑制劑，抑制CaM-KKα和CaM-KKβ的活性，Ki值分別為80 ng/ml和15 ng/ml，并抑制其自身磷酸化活性。STO-609 可抑制 AMPKK 活性并抑制自噬。

靶點(diǎn)

Target	Value
AMPK ()
CaM-KKβ (Cell-free assay)	47 nM(Ki)
CaM-KKα (Cell-free assay)	0.25 μM(Ki)

體外研究

STO-609抑制重組CaM-KKα和CaM-KKβ的活性，Ki值分別為80 ng/ml和15 ng/ml，STO-609還抑制它們的自身磷酸化活性。STO-609對(duì)CaM-KK具有高度選擇性，對(duì)其下游 CaM激酶(CaM-KI and -IV)沒(méi)有顯著作用。在轉(zhuǎn)染的Hela細(xì)胞中，STO-609以劑量依賴方式抑制Ca。

體內(nèi)研究

對(duì)成年小鼠體內(nèi)給藥，STO-609會(huì)引起造骨細(xì)胞的增多、破骨細(xì)胞的減少，對(duì)卵巢切除術(shù)引發(fā)的骨質(zhì)疏松癥具有保護(hù)作用。腦室注射STO-609不影響對(duì)神經(jīng)低血糖癥的負(fù)調(diào)節(jié)反應(yīng)、對(duì)低血糖引起的AMPK激活也沒(méi)有影響。