535-83-1
535-83-1 結(jié)構(gòu)式
基本信息
葫蘆巴堿
煙酸甜菜堿
N-甲菸鹼酸內(nèi)鹽
菸鹼酸N-甲內(nèi)鹽
葫蘆巴堿(標(biāo)準(zhǔn)品)
葫蘆巴堿, 來源于葫蘆巴
1-甲基吡啶-3-甲酸內(nèi)鹽
1-甲基吡啶鎓-3-甲酸內(nèi)鹽
TRIGONELLINE 葫蘆巴堿
Gynesine
Coffearin
Coffearine
Caffearine
Trigonellin
Trigoneline
Trigenolline
TRIGONELLINE
betainnicotinate
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/03/03 | S3220 | 葫蘆巴堿 Trigonelline | 535-83-1 | 5mg | 794.82元 |
| 2026/03/03 | S3220 | 葫蘆巴堿 Trigonelline | 535-83-1 | 25mg | 2432.43元 |
| 2026/03/03 | S3220 | 葫蘆巴堿 Trigonelline | 535-83-1 | 1g | 29787元 |
常見問題列表
| Target | Value |
|
PLCγ1
() | |
|
PI3K
() | |
|
Akt
() | |
|
microtubule
() |
It is found that Trigonelline (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline attenuates H 2 O 2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H 2 O 2 induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirms that Trigonelline significantly reduces the H 2 O 2 induced necrosis and apoptosis in H9c2 cells. However, further increment of Trigonelline concentration against H 2 O 2 can induce the necrosis and apoptosis along with H 2 O 2 .
Trigonelline decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats.