53525-65-8
53525-65-8 結(jié)構(gòu)式
基本信息
5H,10H-二咪唑[1,5-A:1', 5'-D]吡嗪-5,10-二酮
5H,10H-二咪唑并[1,5-A:1, 5-D] 吡嗪-5,10-二酮
DIIMIDAZO[1,5-A:1',5'-D]PYRAZINE-5,10-DIONE
Diimidazo[1,5-a:1’,5’-d)pyrazine-5,10-dione,HCl
DiiMidazo[1,5-a:1',5'-d]pyrazine-5,10-dione, DiHCl
5H,10H-DIIMIDAZO[1,5-A:1', 5'-D] PYRAZINE-5,10-DIONE
5H,10H-DiiMidazo[1,5-a:1', 5'-d] pyrazine-5,10-dione b
5H,10H-Diimidazo[1,5-A:1', 5'-D] pyrazine-5,10-dione ,98%
Diimidazo[1,5-a:1',5'-d]pyrazine-5,10-dione, dihydrochloride
制備方法
1072-84-0
53525-65-8
以1H-咪唑-4-甲酸為原料合成咪唑并[1,5-a:1',5'-d]吡嗪-5,10-二酮的一般步驟：將1H-咪唑-4-甲酸（5g，44.6mmol）懸浮于亞硫酰氯（75mL）中，攪拌下加熱回流18小時(shí)。反應(yīng)完成后，冷卻反應(yīng)混合物，過(guò)濾，用甲苯洗滌，并在高真空下干燥，得到目標(biāo)化合物咪唑并[1,5-a:1',5'-d]吡嗪-5,10-二酮，為黃色固體，收率95%。分子式：C8H4N4O2，分子量：188.14g/mol，熔點(diǎn)：265-268℃。1H NMR (300 MHz, DMSO-d6) δ: 8.24 (d, 1H, CHC-CO), 8.32 (d, 1H, CHC-CO, J=3Hz), 8.88 (d, 1H, CHN), 9.28 (d, 1H, CHN, J=3Hz)。13C NMR (100 MHz, DMSO-d6) δ: 123.99, 124.52, 125.62, 137.26, 139.73, 150.39, 159.68。MS (ESI+, QTof, m/z): 189.0 [M + H]+。
參考文獻(xiàn)：
[1] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 13, p. 6601 - 6610
[2] European Journal of Medicinal Chemistry, 2017, vol. 138, p. 909 - 919
[3] Pharmaceutical Chemistry Journal, 1986, vol. 20, # 7, p. 460 - 463
[4] Khimiko-Farmatsevticheskii Zhurnal, 1986, vol. 20, # 7, p. 799 - 802
[5] Patent: EP1439169, 2004, A1. Location in patent: Page 81-82