537034-15-4
中文名稱
PAOA
英文名稱
N-(2-Aminophenyl)-N'-phenylheptanediamide
CAS
537034-15-4
分子式
C19H23N3O2
分子量
325.4
MOL 文件
537034-15-4.mol
更新日期
2026/07/29 17:21:40
537034-15-4 結(jié)構(gòu)式
基本信息
中文別名
化合物PAOAHDAC抑制劑(NKL 22)
英文別名
NKL 22HDACi-4b
MDK-4154
NKL22, >98%
NKL 22, >98%
HDAC inhibitor IV
Histone Deacetylase Inhibitor IV
N-(2-Aminophenyl)-N'-phenylheptanediamide
N1-(2-AMinophenyl)-N7-phenylheptanediaMide
Heptanediamide, N1-(2-aminophenyl)-N7-phenyl-
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
熔點(diǎn)159-161°C
沸點(diǎn)627.9±40.0 °C(Predicted)
密度1.212±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C冷凍
溶解度可溶于二甲基亞砜、甲醇
酸度系數(shù)(pKa)14?+-.0.70(Predicted)
形態(tài)米色固體
顏色灰白色至淺米色
InChI1S/C19H23N3O2/c20-16-11-7-8-12-17(16)22-19(24)14-6-2-5-13-18(23)21-15-9-3-1-4-10-15/h1,3-4,7-12H,2,5-6,13-14,20H2,(H,21,23)(H,22,24)
InChIKeyZAIULUYKQLVQFH-UHFFFAOYSA-N
應(yīng)用領(lǐng)域
用途1
Histone deacetylase inhibitor IV. A cell-permeable pimeloylanilide compound that acts as a FXN-(frataxin gene) specific HDAC inhibitor. Reverses the silencing of FXN transcription in FRDA (Friedrich鈥檚
ataxia) cells due to hypoacetylation of histones H3 and H4.