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53882-12-5

中文名稱 洛度沙胺
英文名稱 Lodoxamide
CAS 53882-12-5
分子式 C11H6ClN3O6
分子量 311.63
MOL 文件 53882-12-5.mol
更新日期 2026/02/24 11:11:14
53882-12-5 結(jié)構(gòu)式 53882-12-5 結(jié)構(gòu)式

基本信息

中文別名
洛草氨酸
英文別名
Lodoxamida
Lodoxamidum
Unii-spu695od73
LODOXAMIDE USP/EP/BP
Lodoxamidum [inn-latin]
Lodoxamida [inn-spanish]
N,N'-(2-Chlor-5-cyan-3-phenylen)dioxamsaeure
2-[2-chloro-5-cyano-3-(oxaloamino)anilino]-2-oxoacetic acid
2,2'-[(2-Chloro-5-cyano-1,3-phenylene)diimino]bis[2-oxoacetic acid]
Acetic acid, 2,2'-((2-chloro-5-cyano-1,3-phenylene)diimino)bis(2-oxo-

物理化學(xué)性質(zhì)

熔點(diǎn)212° (dec)
密度1.78±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF: 3 mg/ml; DMSO: 5 mg/ml; PBS (pH 7.2): 2 mg/mL
酸度系數(shù)(pKa)2.07±0.50(Predicted)
形態(tài)固體
顏色Off-white to pink
穩(wěn)定性吸濕性

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)有害 (GHS07)
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
洛度沙胺價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2026/06/05HY-14270R洛度沙胺
Lodoxamide (Standard)
53882-12-55 mg1500元
2026/06/05HY-14270R洛度沙胺
Lodoxamide (Standard)
53882-12-510 mg2250元
2026/06/05HY-14270R洛度沙胺
Lodoxamide (Standard)
53882-12-525 mg4050元

常見問題列表

生物活性
Lodoxamide (U-42585E free acid) 是作為肥大細(xì)胞穩(wěn)定劑的抗過敏化合物, 用于研究哮喘和過敏性結(jié)膜炎。
體外研究

Lodoxamide inhibits compound 48/80-induced histamine release and ionophore-induced 45 Ca influx with associated histamine release in purified rat peritoneal mast cells. The chemotactic response of eosinophils to fMLP as well as to IL-5 is significant and dose-dependent inhibited by Lodoxamide. Lodoxamide is also able to strongly inhibit the release of eosinophil peroxidase after IgA-dependent activation and, to a lesser extent, the release of eosinophil cationic protein and eosinophil-derived neurotoxin.

體內(nèi)研究

Lodoxamide has been demonstrated to have cromolyn-like activity when studied in the rat peritoneal mast cell assay (PCA) model3 and in Ascaris antigen-sensitized rhesus monkeys. When given intravenously, orally, or intrabronchially by aerosol, lodoxamide significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized. anesthetized rhesus monkeys. Addition of lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution results in a marked decrease in lung reperfusion injury as demonstrated by increased oxygenation, decreased microvascular permeability, and increased compliance. Patients treated with lodoxamide tromethamine demonstrate an improvement in daytime breathing difficulty, cough, sputum production, and sleep.

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