54-84-2

中文名稱 CINANSERIN HYDROCHLORIDE

英文名稱 CINANSERIN HYDROCHLORIDE

CAS 54-84-2

分子式 C20H25ClN2OS

分子量 376.94

MOL 文件 54-84-2.mol

更新日期 2023/03/20 15:41:23

54-84-2 結構式

基本信息物理化學性質(zhì) 安全數(shù)據(jù) 圖譜信息 CINANSERIN HYDROCHLORIDE價格(試劑級) 常見問題列表

基本信息

中文別名

N-(2-((3-(二甲氨基)丙基)硫代)苯基)-3-苯基丙烯酰胺鹽酸鹽

英文別名

DPTC
maptc
sq10,643
Nsc125717
CINANSERIN
Cinnanserin
DPTC HYDROCHLORIDE
CINANSERIN HYDROCHLORIDE
2'-(3-DIMETHYLAMINOPROPYL-THIO)-CINNAMANILIDE HYDROCHLORIDE
DPTC 2'-(3-Dimethylaminopropylthio)cinnamanilide hydrochloride

物理化學性質(zhì)

密度1.22 g/cm3

儲存條件Inert atmosphere,Store in freezer, under -20°C

溶解度DMSO : 125 mg/mL (331.62 mM; Need ultrasonic)

形態(tài)粉末

顏色Light yellow to yellow

水溶解性Soluble to 50 mM in water

安全數(shù)據(jù)

危險性符號(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險性描述H302-H315-H319-H335

防范說明P261-P280-P301+P312-P302+P352-P305+P351+P338

海關編碼2921490090

圖譜信息

CINANSERIN HYDROCHLORIDE(54-84-2)核磁圖(¹HNMR)

CINANSERIN HYDROCHLORIDE價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-100943	CINANSERIN HYDROCHLORIDE Cinanserin hydrochloride	54-84-2	1 mg	550元
2026/06/05	HY-100943	Cinanserin hydrochloride	54-84-2	5 mg	1400元
2026/06/05	HY-100943	CINANSERIN HYDROCHLORIDE Cinanserin hydrochloride	54-84-2	10mM * 1mLin DMSO	1540元

常見問題列表

生物活性

Cinanserin hydrochloride (SQ 10643) 是一種有效，選擇性和高度親和力的 5-HT2 受體拮抗劑，Ki 為 41 nM。Cinanserin hydrochloride 對 5-HT2 的結合親和力比對 5-HT1 受體 (Ki 為 3500 nM) 的結合親和力高得多。Cinanserin hydrochloride 還是嚴重急性呼吸系統(tǒng)綜合癥冠狀病毒的 3C 樣蛋白酶 (3C-like proteinase) 的抑制劑，可大大減少體外的病毒復制。

靶點

5-HT ₂ Receptor

41 nM (Ki)

3C-like proteinase

體外研究

Cinanserin/Cinanserin hydrochloride have binding affinity to SARS-CoV 3CL ^pro , HCoV-229E 3CL ^pro , with the K _D values of 49.4 μM/78.0 μM for SARS-associated coronavirus (SARS-CoV) 3CL ^pro and 18.2 μM/36.6 μM for human coronavirus 229E (HCoV-229E) 3CL ^pro .
The IC ₅₀ values of Cinanserin and Cinanserin hydrochloride for inhibiting the catalytic activity of SARS-CoV 3CL ^pro are calculated as 4.92 μM and 5.05 μM, respectively, The corresponding IC ₅₀ values for HCoV-229E 3CL ^pro are 4.68 μM and 5.68 μM. None of the compounds have inhibitory activity against HRV-14 3C ^pro at concentrations up to 200 μM.

體內(nèi)研究

Cinanserin (5 mg/kg; intravenous injection; for 2 hours; male Wistar rats) treatment significantly reduces systemic burn edema to shamburn levels. Leukocyte-endothelial interactions are significantly reduced by administration of Cinanserin.

Animal Model:	Male Wistar rats (250 g) underwent thermal injury
Dosage:	5 mg/kg
Administration:	Intravenous injection; for 2 hours
Result:	Significantly reduced systemic burn edema to shamburn levels..