548-61-8
548-61-8 結(jié)構(gòu)式
基本信息
-三氨基三苯甲烷
參(對(duì)胺苯)甲烷
三(4-苯胺基)甲烷
三(4-氨基苯基)甲烷
4,4’,4"-三氨基三苯甲烷
4,4`,4```-三氨基三苯甲烷
-三氨基三苯甲烷/三(4-氨基苯基)甲烷
p-leucaniline
JACS-548-61-8
p-Leucoaniline
paraleucaniline
leucoparafuchsin
Paraleucoaniline
leucoparafuchsine
Leucopararosaniline
tris-4-aminofenylmethan
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
用氫氧化鈉溶液、硫黃配制多硫化鈉，用多硫化鈉作還原劑，在乙醇介質(zhì)中將對(duì)硝基甲苯氧化還原，生成對(duì)氨基苯甲醛。后者在鹽酸存在下與苯胺縮合，生成三（4-氨基苯基）甲烷鹽酸鹽，經(jīng)燒堿中和、蒸出苯胺，再經(jīng)鹽酸酸化、活性炭脫色、液堿中和、干燥、粉碎，得成品。合成反應(yīng)式如下
常見(jiàn)問(wèn)題列表
4,4’,4"-三氨基三苯甲烷是丙型肝炎病毒解旋酶的抑制劑。4,4’,4"-三氨基三苯甲烷具有致癌活性，增加了動(dòng)物直腸內(nèi)皮系統(tǒng)腫瘤的發(fā)生率。
HCV helicase
Tris(4-aminophenyl)methane (Compound 8) shows weak HCV helicase inhibition (30% inhibition at 100 μM). To preserve RNA in a biological sample for analysis, the sample is incubated with an RNA preservative capable of precipitating RNA in an aqueous solution, such as a triphenylmethane dye (e.g., methyl green, crystal violet, pararosaniline, or Tris(4-aminophenyl)methane), cresyl violet, or cobalt ions. RNA preservation may be used in an immunostaining assay and other histochemical methods.