55750-63-5
55750-63-5 結(jié)構(gòu)式
基本信息
6-(馬來酰亞胺基)己酸琥珀酰亞胺酯
EMCS
EPSILON-MALEIMIDOCAPROIC ACID N-HYDROXYSUCCINIMIDE ESTER
N-(6-MALEIMIDOCAPROYLOXY)SUCCINIMIDE
N-(E-MALEIMIDOCAPROYLOXY)SUCCINIMIDE
N-(EPSILON-MALEIMIDOCAPROYLOXY)SUCCINIMIDE
N-[EPSILON-MALEIMIDOCAPROYLOXY]SUCCINIMIDE ESTER
N-SUCCINIMIDYL 6-MALEIMIDOCAPROATE
N-SUCCINIMIDYL 6-MALEIMIDOHEXANOATE
6-Maleimidohexanoic acid N-hydroxysuccinimide ester
N-SUCCINIMIDYL-6-MALEMIDOCAPROATE, 99%
EPISILON-MALEIMIDOCAPROIC ACID N-*HYDROX YSUCCINIMID
6-maleimidohexanoic acid n-succinimidyl ester
N-(6-Maleimidocaproyloxy)succinimideN-Succinimidyl-6-maleimidohexanoate
6-Maleimidocaproic acid N-hydroxysuccinimide ester
N-Succinimidyl 6-Maleimidohexanoate [Cross-linking Reagent]
6-Maleimidocaproic acid N-succinimidyl ester, N-(ε-Maleimidocaproyloxy)succinimide, N-Succinimidyl 6-maleimidocaproate, EMCS
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
Skin Irrit. 2
STOT SE 3
制備方法
6066-82-6
55750-53-3
55750-63-5
在氮?dú)獗Ｗo(hù)下，將4.7g（22mmol）6-馬來酰亞胺基己酸（MC）和25g（22mmol）N-羥基丁二酰亞胺（HOSu）溶解于50ml乙腈中。另將4.5g（22mmol）N,N'-二環(huán)己基碳二亞胺（DCC）溶解于25ml乙腈中，并維持內(nèi)部溫度。在0℃條件下，將DCC溶液緩慢滴加至反應(yīng)混合物中。反應(yīng)混合物于0℃攪拌反應(yīng)2小時(shí)，隨后升至室溫繼續(xù)反應(yīng)過夜。反應(yīng)完成后，過濾除去沉淀，濾餅用乙腈洗滌（10ml×3）。合并濾液，減壓濃縮至干。所得油狀產(chǎn)物于室溫下減壓干燥6小時(shí)，得到6.4g淺棕色固體，即6-(馬來酰亞胺基)己酸琥珀酰亞胺酯，產(chǎn)率為95%。
參考文獻(xiàn)：
[1] Patent: CN107789630, 2018, A. Location in patent: Paragraph 0064; 0065; 0066
[2] Patent: WO2018/178060, 2018, A1. Location in patent: Page/Page column 58; 60; 61
[3] International Journal of Molecular Sciences, 2017, vol. 18, # 9,
[4] Patent: WO2015/95953, 2015, A1. Location in patent: Page/Page column 118
[5] Patent: WO2016/41082, 2016, A1. Location in patent: Page/Page column 97; 98
常見問題列表
6-(馬來酰亞胺基)己酸琥珀酰亞胺酯是一種異雙官能團(tuán)交聯(lián)試劑，與胺和巰基反應(yīng)性的延長(zhǎng)間隔結(jié)合。通常，最初通過pH 7.5緩沖的酰胺鍵與含有初級(jí)胺的分子耦合(6.5-8.5)，第二次耦合是通過pH 6.8緩沖的硫醚鍵與含有游離巰基的分子耦合(6.5-7.0)。
6-(馬來酰亞胺基)己酸琥珀酰亞胺酯可用于酶免疫偶聯(lián)劑和半抗原載體分子偶聯(lián)劑的制備。包含9個(gè)原子鏈接器。與芳香族間隔物相比，延長(zhǎng)的脂肪間隔物在耦合前穩(wěn)定了馬來酰亞胺。
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Non-cleavable
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6-Maleimidohexanoic acid N-hydroxysuccinimide ester is coupled to the peptides, and then conjugated to the Adenovirus vector containing luciferase gene as adenovirus vector carrier.
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/03/03 | H65996 | 6-馬來酰亞胺基己酸 N-丁二烯胺亞胺酯, 95% 6-Maleimidocaproic acid N-succinimidyl ester, 95% | 55750-63-5 | 250mg | 170元 |
| 2026/03/03 | S0577 | 6-(馬來酰亞胺基)己酸琥珀酰亞胺酯 6-Maleimidohexanoic acid N-hydroxysuccinimide ester | 55750-63-5 | 50mg | 930.54元 |
| 2025/12/22 | HY-78961 | 6-(馬來酰亞胺基)己酸琥珀酰亞胺酯 6-Maleimidohexanoic acid N-hydroxysuccinimide ester | 55750-63-5 | 100mg | 100元 |