56472-29-8
中文名稱
2-羥基乳清酸
英文名稱
2-HYDROXYOLEICACID
CAS
56472-29-8
分子式
C18H34O3
分子量
298.46
MOL 文件
56472-29-8.mol
更新日期
2023/03/20 15:41:29
56472-29-8 結構式
基本信息
中文別名
2-羥基油酸2-羥基乳清酸
2-羥基乳清酸-D17
英文別名
2OHOAMinerval
Acumapimod
-d17 Minerva-d17l
2-HYDROXYOLEICACID
α-Hydroxyoleic Acid
α-Hydroxyoleic Acid-d17
cis-2-Hydroxy-9-octadecenoic Acid
(Z)-2-Hydroxyoctadec-9-enoic acid
(9Z)-2-Hydroxy-9-octadecenoic Acid
所屬類別
生物化工：激動劑抑制劑
2-羥基乳清酸價格(試劑級)
| 報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
| 2026/06/05 | HY-129467 | 2-羥基乳清酸 (Rac)-Idroxioleic acid | 56472-29-8 | 1 mg | 650元 |
| 2026/06/05 | HY-129467 | 2-羥基乳清酸 (Rac)-Idroxioleic acid | 56472-29-8 | 5 mg | 1300元 |
| 2026/06/05 | HY-129467 | 2-羥基乳清酸 (Rac)-Idroxioleic acid | 56472-29-8 | 10 mM * 1 mLin DMSO | 1430元 |
常見問題列表
生物活性
Minerval (2-Hydroxyoleic acid) 是一種合成油酸 (OA) 衍生物，能與質膜結合改變脂質組織。Minerval 具有抗腫瘤作用。體外研究
Minerval (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC
50
of ~40 μM.
Minerval (25-50 μM; 72 hours) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis.
Cell Viability Assay
| Cell Line: | Jurkat cells |
| Concentration: | 25 μM, 50 μM, 75 μM |
| Incubation Time: | 24 hours, 48 hours, 72 hours |
| Result: | Impaired Jurkat cell growth in a time- and concentration-dependent manner. |
Western Blot Analysis
| Cell Line: | Jurkat cells |
| Concentration: | 25 μM, 50 μM |
| Incubation Time: | 72 hours |
| Result: | Induced a marked and concentration-dependent increase in the proteolytic cleavage of PARP. |
體內研究
Minerval markedly and significantly inhibits tumour growth in nude mice infected with Jurkat cells.
| Animal Model: | 6-week-old nude male mice (Jurkat cells xenograft model) |
| Dosage: | 600 mg/kg |
| Administration: | Oral administration; daily; for 21 days |
| Result: | Markedly and significantly inhibited tumour growth. |