56632-83-8
中文名稱
4-氨基-1-(2-脫氧-2-氟-beta-D-阿拉伯呋喃基)-2(1H)-嘧啶酮
英文名稱
4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone
CAS
56632-83-8
分子式
C9H12FN3O4
分子量
245.21
MOL 文件
56632-83-8.mol
更新日期
2024/06/05 22:01:00
56632-83-8 結(jié)構(gòu)式
基本信息
中文別名
1-(2-脫氧-2-氟-BETA-D-阿拉伯呋喃基)胞嘧啶4-氨基-1-(2-脫氧-2-氟-beta-D-阿拉伯呋喃基)-2(1H)-嘧啶酮
英文別名
2’-Deoxy-2’-fluoro-β-D-arabinocytidine2'-Deoxy-2'-fluoro-beta-D-arabinocytidine
2'-Fluoro-2'-deoxy-arabinofuranosyl-cytidine
2’-Deoxy-2’-fluoro-beta-D-arabinocytidine, FAC
1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine
FN-008 2'-Fluoro-2'-deoxy-arabinofuranosyl-cytidine
1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosine
1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine HCl
1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine Hydrochloride
4-Amino-1-(2-deoxy-2-fluoro--D-arabinofuranosyl)-2(1H)-pyrimidinone
物理化學(xué)性質(zhì)
熔點(diǎn)136-138 °C
沸點(diǎn)500.1±60.0 °C(Predicted)
密度1.82±0.1 g/cm3(Predicted)
儲(chǔ)存條件Keep in dark place,Inert atmosphere,Room temperature
溶解度DMSO: Soluble
Methanol: Soluble
Methanol: Soluble
酸度系數(shù)(pKa)12.84±0.70(Predicted)
形態(tài)Solid
顏色White to off-white
制備方法
方法1
128495-99-8
56632-83-8
4-氨基-1-(2-脫氧-2-氟-beta-D-阿拉伯呋喃基)-2(1H)-嘧啶酮的合成一般步驟：將4-氨基-1-(3,5-二-O-苯甲?；?2-脫氧-2-氟-BETA-D-阿拉伯呋喃糖基)-2(1H)-嘧啶酮（3.60 mmol）溶解于飽和氨甲醇溶液（30 mL）中，室溫?cái)嚢璺磻?yīng)15小時(shí)。反應(yīng)完成后，減壓濃縮去除溶劑，得到粗產(chǎn)物。通過(guò)硅膠柱色譜法（洗脫劑比例為15:1的氯仿-甲醇）純化粗產(chǎn)物，得到目標(biāo)化合物，收率為80%。1H NMR (CDCl3) δ ppm: 8.10 (d, J = 9.86 Hz, 1H), 7.40 (d, J = 9.82 Hz, 1H), 6.03 (d, J = 9.0 Hz, 1H, H-1'), 5.64 (dd, J = 19.44 Hz, 1H, H-3'), 5.26 (d, J = 48.2 Hz, 1H, H-2'), 4.50 (m, 1H, H-4'), 3.70-3.77 (m, 2H, H-5').
參考文獻(xiàn)：
[1] Patent: EP2177527, 2010, A1. Location in patent: Page/Page column 12
[2] Nucleosides, Nucleotides and Nucleic Acids, 2005, vol. 24, # 5-7, p. 713 - 715
4-氨基-1-(2-脫氧-2-氟-beta-D-阿拉伯呋喃基)-2(1H)-嘧啶酮價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | XW025663283802 | 4-氨基-1-(2-脫氧-2-氟-BETA-D-阿拉伯呋喃基)-2(1H)-嘧啶酮 | 56632-83-8 | 250MG | 1072元 |
| 2026/06/05 | XW025663283801 | 4-氨基-1-(2-脫氧-2-氟-BETA-D-阿拉伯呋喃基)-2(1H)-嘧啶酮 | 56632-83-8 | 100MG | 434元 |
| 2025/05/22 | XW025663283803 | 4-氨基-1-(2-脫氧-2-氟-BETA-D-阿拉伯呋喃基)-2(1H)-嘧啶酮 | 56632-83-8 | 1G | 4335元 |