56985-40-1

中文名稱 9,11-二脫氧基-9Α,11Α-亞甲基環(huán)氧前列腺素 F2Α溶液

英文名稱 U-46619

CAS 56985-40-1

分子式 C21H34O4

分子量 350.49

MOL 文件 56985-40-1.mol

56985-40-1 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 常見問題列表 9,11-二脫氧基-9Α,11Α-亞甲基環(huán)氧前列腺素 F2Α溶液價(jià)格(試劑級(jí))

基本信息

中文別名

9,11-二脫氧基-9Α,11Α-亞甲基環(huán)氧前列腺素
9,11-二脫氧基-11Α,9Α-亞甲基環(huán)氧前列腺素 F2Α
9,11-二脫氧基-9Α,11Α-亞甲基環(huán)氧前列腺素 F2Α溶液
9,11-DIDEOXY-11Α,9Α-EPOXYMETHANOPROSTAGLANDIN F2Α

英文別名

U-46619
9,11-Methanoxy-PGH2
9,11-Methanoepoxy PGH2
11α,9α-Epoxymethanoprostaglandin H2
U-46619 - CAS 56985-40-1 - Calbiochem
9,11-DIDEOXY-11ALPHA,9ALPHA-EPOXYMETHANO
4-alpha,5-beta(z),6-alpha(1e,3s*)))-r-(1-alph
9,11-dideoxy-11α,9α-epoxymethanoprostaglandin f2α
9,11-dideoxy-11A,9A-epoxymethano-*prostaglandin F
9,11-DIDEOXY-9ALPHA,11ALPHA-METHANOEPOXY PGF2ALPHA

所屬類別

生物化工：激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

沸點(diǎn)519.7±30.0 °C(Predicted)

密度1.092±0.06 g/cm3(Predicted)

閃點(diǎn)-10 °C

儲(chǔ)存條件-20°C

溶解度≥100 mg/mL in DMSO, ≥100 mg/mL in Ethanol, ≥100 mg/mL in DMF, ≥2 mg/mL in PBS pH 7.2

酸度系數(shù)(pKa)4.76±0.10(Predicted)

形態(tài)solution

顏色Colorless to light yellow

BRN4267334

InChIKeyLQANGKSBLPMBTJ-WTPHSRJXSA-N

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS) 易燃 (GHS02)

GHS02,GHS07

警示詞危險(xiǎn)

危險(xiǎn)性描述H225-H319-H336

防范說明P210-P305+P351+P338

危險(xiǎn)品標(biāo)志F,Xi

危險(xiǎn)類別碼11-36-66-67

安全說明16-26

危險(xiǎn)品運(yùn)輸編號(hào)UN 1231 3/PG 2

WGK Germany2

RTECS號(hào)MJ9681090

F8-10-23

存儲(chǔ)類別3 - Flammable liquids

危險(xiǎn)性類別Eye Irrit. 2
Flam. Liq. 2
STOT SE 3

毒性LD50 intravenous in mouse: 66ug/kg

常見問題列表

用途

U-46619是一種PGH2類似物，可以用作血栓烷A2（TP）受體激動(dòng)劑，影響人類血管平滑肌的促有絲分裂生長(zhǎng)。U 46619是穩(wěn)定的血栓烷A2模擬物，是H2內(nèi)過氧化物前列腺素的類似物，用作血管收縮劑和血栓烷受體激動(dòng)劑。

生物活性

U-46619 (9,11-Methanoepoxy PGH2) 是一種穩(wěn)定的血栓素 A2 (TXA2) 的類似物，也是一種有效的 TXA2 激動(dòng)劑。

靶點(diǎn)

TXA2

體外研究

U-46619 (1 nM-10 μM) causes platelets shape change and aggregation in a concentration-dependent manner, and with EC ₅₀ s of 0.58 μM and 0.013 μM for aggregation and shape change, respectively.
U-46619 (10 nM-10 μM) increases internal Ca ²⁺ concentration ([Ca ²⁺ ]i) and activates phosphoinositide (PI) hydrolysis in a concentration-dependent manner with a similar concentration-dependency.
U-46619 (3 nM-10 μM) also activates GTPase concentration-dependently in the membranes derived from platelets.
U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways.

體內(nèi)研究

U-46619 (5 μg/kg; i.v.) increases blood pressure in male spontaneously hypertensive rats (SHR).

Animal Model:	12-15 weeks-old male and female SHR
Dosage:	5 μg/kg
Administration:	Intravenous injection
Result:	Induceed a significant increase of MABP after 1 min in male SHR.

9,11-二脫氧基-9Α,11Α-亞甲基環(huán)氧前列腺素 F2Α溶液價(jià)格(試劑級(jí))