57470-78-7

中文名稱鹽酸塞利洛爾

英文名稱 Celiprolol hydrochloride

CAS 57470-78-7

EINECS 編號 260-752-2

分子式 C20H34ClN3O4

MDL 編號 MFCD00941500

分子量 415.95

MOL 文件 57470-78-7.mol

更新日期 2026/07/15 12:30:43

57470-78-7 結(jié)構(gòu)式

基本信息物理化學性質(zhì) 安全數(shù)據(jù) 應用領(lǐng)域鹽酸塞利洛爾價格(試劑級) 常見問題列表

基本信息

中文別名

3-[3-乙酰-4-(3-叔丁胺基)-2-羥基丙氧基]苯基-1,1-二乙基脲鹽酸鹽
鹽酸塞利洛爾
2,2,3,3,4,4,5,5,6-九溴聯(lián)苯醚

英文別名

3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea hydrochloride
CELIPROLOL HYDROCHLORIDE
3-(3-acetil-4-(3-tert-butilamino-2-hidroxipropoxi)fenil)-1,1-dietilureahcl
3-(3-acetyl-4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)phenyl)-1,1-ure
3-(3-acetyl-4-(3-tert-butylamino-2-hydroxypropoxy)phenyl)-1,1-diethylharnsto
3-(3-acetyl-4-(3-tert-butylamino-2-hydroxypropoxy)phenyl)-1,1-diethylureahyd
celiprololclorhidrato
celiprololhydrochlorid
clorhidratodeceliprolol
ffhcl
rhc-5320a
selectrol
st1396clorhidrato
st1396hydrochlorid
st1396hydrochloride
Celipolol Hydrochloride
3-[3-acetyl-4-[3-[(tert-butyl)amino]-2-hydroxypropoxy]phenyl]-1,1-diethyluronium chloride
Urea, N-3-acetyl-4-3-(1,1-dimethylethyl)amino-2-hydroxypropoxyphenyl-N,N-diethyl-, monohydrochloride
CELIPOLOLHYDROCHLORIDE(SUBJECTTOPATENTFREE)
Celectol

所屬類別

原料藥：抗心律失常藥

物理化學性質(zhì)

熔點197-200°C (dec.)

RTECS號YR6560000

儲存條件Refrigerator

溶解度Freely soluble in water and in methanol, soluble in ethanol (96 per cent), very slightly soluble in methylene chloride.

形態(tài)neat

顏色白色至灰白色

水溶解性Soluble in ethanol, methanol and water

InChI1S/C20H33N3O4.ClH/c1-7-23(8-2)19(26)22-15-9-10-18(17(11-15)14(3)24)27-13-16(25)12-21-20(4,5)6;/h9-11,16,21,25H,7-8,12-13H2,1-6H3,(H,22,26);1H

InChIKeyVKJHTUVLJYWAEY-UHFFFAOYSA-N

SMILES[Cl-].N(CC)(CC)C(=O)Nc1cc(c(cc1)OCC(O)CNC(C)(C)C)C(=O)C.[H+]

CAS 數(shù)據(jù)庫57470-78-7(CAS DataBase Reference)

安全數(shù)據(jù)

危險性符號(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險性描述H303

防范說明P270-P301+P312-P403-P501c

WGK GermanyWGK 3

存儲類別11 - Combustible Solids

毒性LD50 in male mice, rats (mg/kg): 56.2, 68.3 i.v.; 1834, 3826 orally (Wendtlandt, Pittner)

應用領(lǐng)域

用途一

抗高血壓藥。

鹽酸塞利洛爾價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/07/06	S5923	鹽酸塞利洛爾 Celiprolol hydrochloride	57470-78-7	2mg	795.34元
2026/07/06	S5923	鹽酸塞利洛爾 Celiprolol hydrochloride	57470-78-7	10mg	1777.23元

常見問題列表

生物活性

Celiprolol是β1-adrenoceptor拮抗劑，具有部分β2受體激動劑活性。

靶點

β1-andrenoceptor

體內(nèi)研究

Celiprolol (5 or 50 mg/kg; p.o. every day for 12 weeks) has a moderate antihypertensive action at the dose of 50 mg/kg, and significantly reduces media smooth muscle hypertrophy of the mesenteric artery in SHR.

Animal Model:	Male spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto (WKY) rats (8 weeks old)
Dosage:	5, 50 mg/kg
Administration:	P.o. every day (administered in drinking water) for 12 weeks
Result:	Attenuated the rise in blood pressure significantly at the dose of 50 mg/kg in SHR. Did not significantly affect absolute heart or body weights. Reduced the average medial thickness of the mesenteric artery in SHR.