58-28-6
中文名稱
鹽酸去甲咪嗪
英文名稱
DESIPRAMINE HYDROCHLORIDE
CAS
58-28-6
分子式
C18H23ClN2
分子量
302.84
MOL 文件
58-28-6.mol
更新日期
2024/06/25 17:15:56
58-28-6 結構式
基本信息
中文別名
鹽酸地昔帕明鹽酸去甲咪嗪
鹽酸去甲丙咪嗪
去甲丙咪嗪鹽酸鹽
鹽酸去甲咪嗪雜質
5-[3-(甲基氨基)丙基]-5H-二苯并[B,F]氮雜卓鹽酸鹽
3-(5,6-二氫苯并[B][1]苯并氮雜卓-11-基)-N-甲基丙-1-胺
3-(5,6-二氫苯并[B][1]苯并氮雜卓-11-基)-N-甲基-丙-1-胺
[3-(10,11-二氫-5H-二苯并[B,F]氮雜卓-5-基)丙基]甲胺鹽酸鹽
3-(5,6-二氫苯并[B][1]苯并氮雜卓-11-基)-N-甲基丙-1-胺鹽酸鹽
英文別名
g35020jb8181
ex4355
Petylyl
Nortimil
norpramin
pertofran
RMI-9384A
nsc-114901
pertofrane
所屬類別
原料藥：抗抑郁、躁狂藥物理化學性質
熔點214-2160C
閃點11 °C
儲存條件2-8°C
儲存條件2-8°C
溶解度H2O: 50 mg/mL
溶解度H2O:50 mg/mL
形態(tài)powder
顏色white to off-white
水溶解性溶于水至100mM
InChI1S/C18H22N2.ClH/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20;/h2-5,7-10,19H,6,11-14H2,1H3;1H
InChIKeyXAEWZDYWZHIUCT-UHFFFAOYSA-N
SMILESCl[H].CNCCCN1c2ccccc2CCc3ccccc13
安全數(shù)據(jù)
警示詞危險
危險品標志Xn,T,F
危險品運輸編號UN 1230 3/PG 2
危險品運輸編號UN 1230 3/PG 2
WGK Germany3
WGK Germany3
RTECS號HO0525000
REACH 注冊登記Active
海關編碼2933996100
存儲類別11 - Combustible Solids
危險性類別Acute Tox. 4 Oral
Eye Irrit. 2
Resp. Sens. 1
Skin Irrit. 2
Skin Sens. 1
STOT SE 3
Eye Irrit. 2
Resp. Sens. 1
Skin Irrit. 2
Skin Sens. 1
STOT SE 3
毒性LD50 in mice, rats (mg/kg): 500, 385 orally; 94, 48 i.p.; 420, 183 s.c. (Eriksoo, Rohte)
鹽酸去甲咪嗪價格(試劑級)
| 報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
| 2026/06/05 | HY-B1272R | 鹽酸去甲咪嗪 Desipramine hydrochloride (Standard) | 58-28-6 | 5 mg | 320元 |
| 2026/06/05 | HY-B1272R | 鹽酸去甲咪嗪 Desipramine hydrochloride (Standard) | 58-28-6 | 10 mg | 470元 |
| 2026/06/05 | HY-B1272R | 鹽酸去甲咪嗪 Desipramine hydrochloride (Standard) | 58-28-6 | 25 mg | 810元 |
常見問題列表
生物活性
Desipramine hydrochloride 是去甲腎上腺素轉運蛋白 (NET), 5-羥色胺轉運體 (SERT) 和多巴胺轉運 (DAT) 的抑制劑，其 Ki 值分別為 4, 61 和 78,720 nM。靶點
Ki: 4 nM (NET), 61 nM (SERT), 78720 nM (DAT)
體內研究
Treatment of rats with Desipramine hydrochloride for 14 days reduces norepinephrine transporter (NET) expression in a dose-dependent manner, as indicated by a reduction of the specific binding of 3 H-nisoxetine to the NET in preparations of cerebral cortex (F (3,16) =4.33, p<0.05) and hippocampus (F (3,16) =4.34, p<0.05). This NET down regulation is observed 2 days after discontinuation of chronic Desipramine hydrochloride treatment, a time when plasma and brain concentrations of Desipramine hydrochloride and desmethyldesipramine are undetectable (ie below the 25 ng detection limit of the assay).