58-49-1

中文名稱血管緊張素

英文名稱 Angiotensin acetate

CAS 58-49-1

分子式 C49H69N13O12

分子量 1032.15

MOL 文件 58-49-1.mol

更新日期 2026/05/29 13:08:24

58-49-1 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 應(yīng)用領(lǐng)域安全數(shù)據(jù) 常見問題列表血管緊張素價(jià)格(試劑級(jí))

基本信息

中文別名

血管緊張素
[VAL5]-血管緊張素 II 乙酸鹽水合物
醋酸血管緊張素 II ANGIOTENSINII ACETATE

英文別名

DRVYVHPF
Angiotensin acetate
[VAL5]-ANGIOTENSIN II
Angiotensin II 5-valine
(5-L-Val)-Angiotensin II
ANGIOTENSIN II, 5-L-VALINE-
[VAL5] ANGIOTENSIN II HUMAN
ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE
L-ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE
H-ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE-OH

所屬類別

原料藥：抗休克血管活性藥

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C

密度1.45±0.1 g/cm3(Predicted)

酸度系數(shù)(pKa)3.56±0.10(Predicted)

形態(tài)粉末

顏色White to off-white

水溶解性Water : ≥ 257.5 mg/mL (249.48 mM)

序列H-Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH

InChIKeyJVCJXRGXGITABA-IAQGTVMASA-N

CAS 數(shù)據(jù)庫58-49-1

應(yīng)用領(lǐng)域

參考質(zhì)量標(biāo)準(zhǔn)

外觀:白色粉末
純度(HPLC) ≥98.0%
醋酸根含量5.0%～12.0%
水分含量≤8.0%
肽含量≥80.0%

安全數(shù)據(jù)

WGK Germany3

常見問題列表

理化性質(zhì)

血管緊張素是一類具有極強(qiáng)的縮血管和刺激腎上腺皮質(zhì)分泌醛固酮等作用的肽類物質(zhì)，參與血壓及體液的調(diào)節(jié)?？煞譃檠芫o張素Ⅰ-Ⅶ，而目前在血管緊張素Ⅰ，血管緊張素Ⅱ，血管緊張素Ⅲ中研究較多。

生物活性

Angiotensin II 5-valine 是血管緊張素受體 (angiotensin receptor) 的激動(dòng)劑。

靶點(diǎn)

Angiotensin receptor.

體內(nèi)研究

By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg). As shown, the development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone.

血管緊張素價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2025/12/22	HY-P0108	血管緊張素 Angiotensin II 5-valine	58-49-1	5mg	450元
2025/12/22	HY-P0108	血管緊張素 Angiotensin II 5-valine	58-49-1	10mg	550元
2025/12/22	HY-P0108	血管緊張素 Angiotensin II 5-valine	58-49-1	10mM * 1mLin Water	624元