58-60-6
58-60-6 結構式
基本信息
氨基核苷嘌呤霉素
氨基核酸嘌呤酶素
博羅霉素氨基核苷
嘌呤霉素氨基核苷
3'-氨基-3'-脫氧-N,N-二甲基腺苷
Aids000507
Aids-000507
aminonucleoside
3′-Amino-3′-deoxy-N6
aminonucleosidepuromycin
PuroMycin aMinonucleosid
PUROMYCIN AMINONUCLEOSIDE
stylomycinaminonucleoside
puromycin aminonucleoside (PAN)
物理化學性質
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/06/05 | HY-15695R | 維生素E醋酸酯 Puromycin aminonucleoside (Standard) | 58-60-6 | 5 mg | 1410元 |
| 2026/06/05 | HY-15695 | 維生素E醋酸酯 Puromycin aminonucleoside | 58-60-6 | 1 mg | 250元 |
| 2026/06/05 | HY-15695R | 維生素E醋酸酯 Puromycin aminonucleoside (Standard) | 58-60-6 | 10 mg | 2250元 |
常見問題列表
Puromycin aminonucleoside (NSC 3056) 是一種氨基核苷類抗生素，為嘌呤霉素類似物。Puromycin aminonucleoside 誘導細胞凋亡 (apoptosis)。Puromycin aminonucleoside 可逆抑制二肽基肽酶 (dipeptidyl peptidase II) 和胞漿丙氨酸氨基肽酶。嘌呤霉素氨基核苷是抗生素嘌呤霉素的氨基核苷部分。
Puromycin aminonucleoside (NSC 3056) (30 μg/mL) markedly increases p53 protein levels in podocytes. Puromycin aminonucleoside (NSC 3056)-induced podocyte apoptosis is p53 dependent. Puromycin aminonucleoside (NSC 3056) induces podocyte apoptosis in a time-dependent manner. The IC 50 values for PMAT-expressing and vector-transfected cells are 48.9 and 122.1 μM, respectively, suggesting expression of PMAT-enhanced cell sensitivity to Puromycin aminonucleoside. Puromycin aminonucleoside (NSC 3056) (250 μM) is toxic to both PMAT-expressing and vector-transfected cells. Puromycin aminonucleoside (NSC 3056) uptake in PMAT-expressing cells is fourfold higher at pH 6.6 than that at pH 7.4.
The number of podocytes per glomerulus is 95.5±17.6 in the control rats, 90.7 on Day 4 in Puromycin aminonucleoside (NSC 3056) (8 mg/100 g, i.v.)-treated nephrosis rats. The amount of nephrin per glomerulus in control rats is 1.02±0.11 fmol and those in Puromycin aminonucleoside (NSC 3056) nephrosis rats are reduced to 0.46±0.06 fmol and 0.35±0.04 fmol on Day 4 and Day 7. The nephrin amount per podocyte is significantly decreased association with the development of proteinuria in Puromycin aminonucleoside (NSC 3056) nephrosis rats. Rats given Puromycin aminonucleoside (NSC 3056) (100 mg/kg, s.c.) gain less weight and their serum creatinine levels are higher than the control rats.