599150-20-6
中文名稱(chēng)
MFCD03312466
英文名稱(chēng)
2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin
CAS
599150-20-6
分子式
C27H29NO6
分子量
463.52
MOL 文件
599150-20-6.mol
更新日期
2026/07/15 17:50:54
599150-20-6 結(jié)構(gòu)式
基本信息
英文別名
HPI 1Hedgehog Pathway Inhibitor 1
Hh Signaling Antagonist XII, HPI-1
Hh Signaling Antagonist XII, HPI-1 - CAS 599150-20-6 - Calbiochem
2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroqui
2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquino
2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin
4-(3-Hydroxyphenyl)-1-(2-methoxyethyl)-7-(2-methoxyphenyl)-2-methyl-4,6,7,8-tetrahydroquinolin-5(1H)-one
2-methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
2-Methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylate
物理化學(xué)性質(zhì)
沸點(diǎn)638.2±55.0 °C(Predicted)
密度1.28±0.1 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)9.67±0.10(Predicted)
形態(tài)淡黃色固體
顏色Light yellow to yellow
InChI1S/C27H29NO6/c1-16-24(27(31)34-12-11-32-2)25(17-7-6-8-19(29)13-17)26-21(28-16)14-18(15-22(26)30)20-9-4-5-10-23(20)33-3/h4-10,13,18,25,28-29H,11-12,14-15H2,1-3H3
InChIKeyZXSWZQSYZYMZKS-UHFFFAOYSA-N
常見(jiàn)問(wèn)題列表
概述
GLI antagonist-1 是一種有效的 GLI 拮抗劑，IC50 值為 1.1 μM。GLI antagonist-1 顯示出抗增殖活性。GLI antagonist-1 降低 GLI1 mRNA 表達(dá)。GLI antagonist-1 以劑量依賴(lài)性方式抑制集落形成。