60668-24-8
中文名稱
阿拉磷
英文名稱
(S)-ALANYL-(R)-1-AMINOETHYLPHOSPHONIC ACID
CAS
60668-24-8
分子式
C5H13N2O4P
分子量
196.14
MOL 文件
60668-24-8.mol
60668-24-8 結(jié)構(gòu)式
基本信息
中文別名
阿拉磷L-丙氨酰-L-1-氨基乙基膦酸
英文別名
ALAPHOSPHINALAFOSFALIN
Alafosfalin >97%
L-ALANYL-L-ALA(P)-OH
L-ALANYL-L-1-AMINOETHYLPHOSPHONIC ACID
(S)-ALANYL-(R)-1-AMINOETHYLPHOSPHONIC ACID
[(1R)-1-[[(2S)-2-Aminopropanoyl]amino]ethyl]phosphonic acid
L-ALANYL-L-ALA(P)-OH, (S)-ALANYL-(R)-1-AMINOETHYLPHOSPHONIC ACID
Phosphonic acid, P-[(1R)-1-[[(2S)-2-amino-1-oxopropyl]amino]ethyl]-
(S)-Alanyl-(R)-1-aminoethylphosphonic acid, Alafosfalin, Alaphosphin
物理化學(xué)性質(zhì)
熔點295-296° (dec)
比旋光度D20 -44.0° (c = 1 in H2O)
密度1.395±0.06 g/cm3(Predicted)
儲存條件2-8°C
溶解度Methanol (Slightly), Water (Sligthly)
酸度系數(shù)(pKa)2.60±0.10(Predicted)
形態(tài)粉末
顏色無色或白色
旋光度 (Optical Rotation)[α]20/D 45±2°, c = 1% in H2O
Merck13,202
BRN4801790
常見問題列表
生物活性
Alafosfalin 是一種細(xì)胞壁生物合成抑制劑。Alafosfalin 是一種磷酸二肽，具有抗菌 (antibacterial) 特性。靶點
Antibacterial
體外研究
Alafosfalin is highly active against Escherichia coli and moderately active against Serratia , Klebsiella , Enterobacter , and Citrobacter , but less active against gram-positive organisms than were beta-lactams such as cephazolin or ampicillin and inactive against indole-positive Proteus , Pseudomonas , and Acinetobacter .
體內(nèi)研究
After s.c. administration to rats, Alafosfalin is rapidly absorbed with half-lives (t 1/2 ) of approximately 20 minutes.
| Animal Model: | Pairs of male SpragueDawley rats (250 to 350 g) |
| Dosage: | 20, 100, and 500 mg/ kg (single doses) or 800 mg/kg per day for 14 days (Pharmacokinetic Analysis) |
| Administration: | Administrated by s.c. |
| Result: | Rapidly absorbed; peak concentrations were found within 20 minutes of dosing with half-lives of approximately 20 minutes. |