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62289-81-0

中文名稱 N-(吡啶-3-基)噻吩-2-羧酰胺
英文名稱 N-pyridin-3-ylthiophene-2-carboxamide
CAS 62289-81-0
分子式 C10H8N2OS
分子量 204.25
MOL 文件 62289-81-0.mol
更新日期 2026/07/19 15:37:40
62289-81-0 結(jié)構(gòu)式 62289-81-0 結(jié)構(gòu)式

基本信息

中文別名
N-(吡啶-3-基)噻吩-2-羧酰胺
英文別名
SW-106065
N-pyridin-3-ylthiophene-2-carboxamide
2-Thiophenecarboxamide, N-3-pyridinyl-

物理化學(xué)性質(zhì)

沸點270.8±15.0 °C(Predicted)
密度1.352±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO: 100 mg/mL (489.60 mM)
酸度系數(shù)(pKa)12.39±0.70(Predicted)
形態(tài)Solid
顏色Off-white to light yellow

安全數(shù)據(jù)

危險性符號(GHS)有害 (GHS07)
GHS07
警示詞警告
危險性描述H302-H315-H319-H335
N-(吡啶-3-基)噻吩-2-羧酰胺價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2026/06/05HY-124778N-(吡啶-3-基)噻吩-2-羧酰胺
SW106065
62289-81-01 mg400元
2026/06/05HY-124778N-(吡啶-3-基)噻吩-2-羧酰胺
SW106065
62289-81-05mg1000元
2026/06/05HY-124778N-(吡啶-3-基)噻吩-2-羧酰胺
SW106065
62289-81-010mM * 1mLin DMSO1100元

常見問題列表

生物活性
SW106065 是惡性周圍神經(jīng)鞘瘤 (MPNST) 的凋亡 (apoptosis) 誘導(dǎo)劑。SW106065 以 EC50 為 1 μM 來抑制 sMPNST 細(xì)胞和其他模型中 MPNST 的 ATP 消耗。SW106065 可用于 MPNST 的研究。
體外研究

SW106065 (Compound 21, Cpd21) inhibits the human MPNST cell lines growth in a dose-dependent manner, and EC 50 concentrations of 439 nM and 753.6 nM for S462 and SNF96.2 cells, respectively. SW106065 remains nontoxic to normally dividing Schwann cells or mouse embryonic fibroblasts.
SW106065 (Cpd21; 0.25-5 μM; 24 hours; sMPNST cells) treatment shows a decreased percentage of cells in S phase, and a corresponding increased percentage in G1/G0 and G2/M.
SW106065 (Cpd21; 0.25-5 μM; 24 hours; sMPNST cells) treatment decreases the levels of cyclin A2, cyclin B1, cyclin D1, cyclin E, cdk4, and cdk6. And increases levels of cdkn1a and cdkn2a mRNA were observed in a dose-dependent manner. SW106065 (Cpd21; 0.25-5 μM; 24 hours; sMPNST cells) treatment decreases the levels of Cyclin D1 protein.
SW106065 (Cpd21) treatment significant increase in the percentage of apoptotic cells.

Cell Cycle Analysis

Cell Line: sMPNST cells
Concentration: 0.25 μM, 0.5 μM, 1 μM, 2.5 μM, and 5 μM
Incubation Time: 24 hours
Result: Showed a decreased percentage of cells in S phase, and a corresponding increased percentage in G1/G0 and G2/M.

RT-PCR

Cell Line: sMPNST cells
Concentration: 0.25 μM, 0.5 μM, 1 μM, 2.5 μM, and 5 μM
Incubation Time: 24 hours
Result: Decreased levels of cyclin A2, cyclin B1, cyclin D1, cyclin E, cdk4, and cdk6. Increased levels of cdkn1a and cdkn2a mRNA were observed in a dose-dependent manner.

Western Blot Analysis

Cell Line: sMPNST cells
Concentration: 0.25 μM, 0.5 μM, 1 μM, 2.5 μM, and 5 μM
Incubation Time: 24 hours
Result: Decreased levels of Cyclin D1 protein.
體內(nèi)研究

SW106065 (Cpd21; 40 mg/kg; intraperitoneal injection; twice per day for 4 weeks) treatment can be delivered to mice in concentrations to sufficiently penetrate sMPNST tissue, and inhibit tumor development.

Animal Model: NCR-nu/nu female mice (6-7 week old) injected with MPNST cells
Dosage: 40 mg/kg
Administration: Intraperitoneal injection; twice per day for 4 weeks
Result: Reduced MPNST burden in a mouse allograft model.
"62289-81-0" 相關(guān)產(chǎn)品信息
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