64118-84-9
中文名稱
2-((2,6-二氯-4-羥基苯基)氨基)苯乙酸
英文名稱
2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID
CAS
64118-84-9
分子式
C14H11Cl2NO3
分子量
312.15
MOL 文件
64118-84-9.mol
更新日期
2026/05/30 18:25:34
64118-84-9 結(jié)構(gòu)式
基本信息
中文別名
羥基雙氯芬酸4'-羥基雙氯芬酸
4'-羥基雙氯滅痛
4′-羥基雙氯芬酸 溶液
2-((2,6-二氯-4-羥基苯基)氨基)苯乙酸
2-((2,6-二氯-4-羥基苯基)氨基)苯乙酸/4'-羥基雙氯滅痛
英文別名
4-OHD4'-OHD
Hydroxydiclofenac
4'-HYDROXYDICLOFENAC
4-HYDROXY DICLOFENAC
DICLOFENAC, 4'-HYDROXY-
4'-HYDROXYDICLOFENAC STANDARD
4′-Hydroxydiclofenac solution
(o-(2,6-dichloro-4-hydroxyanilino)phenyl)aceticacid
(o-(2,6-dichloro-4-hydroxyanilino)phenyl)-aceticaci
所屬類別
分析化學(xué)：離子色譜試劑物理化學(xué)性質(zhì)
熔點178-185°C dec.
沸點432.7±45.0 °C(Predicted)
密度1.520±0.06 g/cm3(Predicted)
閃點2℃
儲存條件−20°C
溶解度溶于DMSO、乙醇或甲醇
酸度系數(shù)(pKa)4.17±0.10(Predicted)
形態(tài)neat
顏色White to off-white
BRN4198042
穩(wěn)定性感光
主要應(yīng)用clinical testing
InChI1S/C14H11Cl2NO3/c15-10-6-9(18)7-11(16)14(10)17-12-4-2-1-3-8(12)5-13(19)20/h1-4,6-7,17-18H,5H2,(H,19,20)
InChIKeyKGVXVPRLBMWZLG-UHFFFAOYSA-N
SMILESOC(=O)Cc1ccccc1Nc2c(Cl)cc(O)cc2Cl
安全數(shù)據(jù)
警示詞危險
危險品標志T,N,Xn,F
危險品運輸編號UN 2811 6.1/PG 3
WGK Germany3
RTECS號AG6542800
危險等級6.1
存儲類別3 - Flammable liquids
危險性類別Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Flam. Liq. 2
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Flam. Liq. 2
常見問題列表
生物活性
4'-Hydroxy diclofenac 是具有口服活性的 Diclofenac (HY-15036) 通過細胞色素 P450 2C9 (CYP2C9) 的代謝產(chǎn)物。4'-Hydroxy diclofenac 具有抗炎和鎮(zhèn)痛作用。體內(nèi)研究
A single oral administration of Diclofenac to humanized mice, the unchanged drug in plasma peaks at 0.25 hour and then declines with a half-life (t
1/2
) of 2.4 hours. 4'-Hydroxy diclofenac also peaks at 0.25 hour and is undetectable within 24 hours. The plasma concentration of unchanged 4'-Hydroxy diclofenac peaks at 0.25 hour and declines rapidly in Humanized chimeric mice received of 4'-Hydroxy diclofenac (10 mg/kg; a single oral).