65089-17-0
中文名稱(chēng)
匹立昔爾
英文名稱(chēng)
Pirinixil
CAS
65089-17-0
分子式
C16H18ClN3OS
分子量
366.87
MOL 文件
65089-17-0.mol
65089-17-0 結(jié)構(gòu)式
基本信息
中文別名
匹立昔爾化合物 T13821
英文別名
Pirinixil2-[[4-Chloro-6-(2,3-dimethylphenylamino)-2-pyrimidinyl]thio]-N-(2-hydroxyethyl)acetamide
2-[[4-Chloro-6-[(2,3-dimethylphenyl)amino]pyrimidin-2-yl]thio]-N-(2-hydroxyethyl)acetamide
Acetamide, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-N-(2-hydroxyethyl)-
物理化學(xué)性質(zhì)
熔點(diǎn)145°C
沸點(diǎn)609.6±55.0 °C(Predicted)
密度1.2894 (rough estimate)
折射率1.6100 (estimate)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)13.27±0.46(Predicted)
常見(jiàn)問(wèn)題列表
生物活性
Pirinixil 是一種低毒性降血脂藥。體內(nèi)研究
Pirinixil is a hypolipidemic agent of low toxicity. Total cholesterol is reduced by Pirinixi in the spleen, kidney and heart of rats. Pirinixil decreases the estimated total body cholesterol approximately 40%. Pirinixil increases plasma cholesterol levels significantly without affecting plasma triglycerides. Liver cholesterol and triglycerides are markedly reduced by Pirinixil, while combined plasma and liver lipid levels decrease approximately 20%. Liver HMG-CoA reductase activity is not affected, but cholesterol 7α-hydroxylase is significantly reduced by Pirinixil.