6639-79-8
6639-79-8 結(jié)構(gòu)式
基本信息
6-氯-2,3-二羥基喹惡啉
6-氯-2,3(1H,4H)-喹喔啉二酮
6-氯-2,3-二氧代-1,2,3,4-四氫喹喔啉
6-CHLOROQUINOXALINE-2,3-DIOL
6-Chloro-2,3-dihydroxyqunoxaline
2,3-DIHYDROXY-6-CHLOROQUINOXALINE
6-Chloro-2,3-dihydroxyquinoxaline
1-(2-chloroethoxy)-2-phenylbenzene
2,3-Dihydroxy-6-chloroquinoxaline ,97%
6-chloro-1,4-dihydro-3-quinoxalinedione
6-CHLORO-1,4-DIHYDRO-2,3-QUINOXALINEDIONE
6-chloro-1,4-dihydroquinoxaline-2,3-dione
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
95-83-0
95-92-1
6639-79-8
步驟1: 6-氯喹喔啉-2,3(1H,4H)-二酮的合成 向100 mL圓底燒瓶中加入4-氯-1,2-苯二胺(5.3 g, 37 mmol)和草酸二乙酯(31 mL)。將反應(yīng)混合物在回流條件下攪拌過夜。反應(yīng)進(jìn)程通過薄層色譜(TLC, 展開劑比例為乙酸乙酯/石油醚=1:10)進(jìn)行監(jiān)測。反應(yīng)完成后，通過過濾收集沉淀物，用乙醇(20 mL)洗滌，干燥后得到淺黃色固體產(chǎn)物7.0 g，收率96%。產(chǎn)物表征數(shù)據(jù)如下：1H NMR (300 MHz, DMSO-d6) δ: 11.96 (br, 2H), 7.11 (m, 3H); MS m/z: 195 (M-H+)。
參考文獻(xiàn)：
[1] Journal of Medicinal Chemistry, 1990, vol. 33, # 8, p. 2240 - 2254
[2] Patent: US2010/120741, 2010, A1. Location in patent: Page/Page column 17
[3] Patent: WO2011/112731, 2011, A2. Location in patent: Page/Page column 66
[4] Journal of Organic Chemistry, 2017, vol. 82, # 19, p. 10077 - 10091
[5] Synthetic Communications, 2004, vol. 34, # 8, p. 1349 - 1357