664993-53-7
中文名稱
JW-55
英文名稱
JW55
CAS
664993-53-7
分子式
C25H26N2O5
分子量
434.48
MOL 文件
664993-53-7.mol
更新日期
2026/07/13 11:29:16
664993-53-7 結(jié)構(gòu)式
基本信息
中文別名
Β-CATENIN抑制劑(JW 55)N-(4-((4-(4-甲氧基苯基)四氫-2H-吡喃-4-基)甲基氨基甲酰基)苯基)呋喃-2-甲酰胺
N-[4-[[[[四氫-4-(4-甲氧基苯基)-2H-吡喃-4-基]甲基]氨基]羰基]苯基]-2-呋喃甲酰胺
N-[4-[[[[四氫-4-(4-甲氧基苯基)-2H-吡喃-4-基]甲基]氨基]羰基]苯基]-2-呋喃甲酰胺(JW55)
英文別名
JW55CS-1095
JW 55
JW-55
JW 55, >=98%
Tankyrase1/2 Inhibitor IV, JW55
Tankyrase1/2 Inhibitor IV, JW55 - CAS 664993-53-7 - Calbiochem
N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE
N-(4-((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)MethylcarbaMoyl)phenyl)furan-2-carboxaMide
N-(4-(((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamid
N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide
所屬類別
生物化工：激動劑抑制劑物理化學(xué)性質(zhì)
熔點(diǎn)153-155 °C
沸點(diǎn)572.6±50.0 °C(Predicted)
密度1.235±0.06 g/cm3(Predicted)
儲存條件Inert atmosphere,2-8°C
溶解度DMSO：可溶15mg/mL，澄清
酸度系數(shù)(pKa)12.41±0.70(Predicted)
形態(tài)粉末
顏色白色至米色
InChI1S/C25H26N2O5/c1-30-21-10-6-19(7-11-21)25(12-15-31-16-13-25)17-26-23(28)18-4-8-20(9-5-18)27-24(29)22-3-2-14-32-22/h2-11,14H,12-13,15-17H2,1H3,(H,26,28)(H,27,29)
InChIKeyZJZWZIXSGNFWQQ-UHFFFAOYSA-N
SMILESO1C=CC=C1C(NC1=CC=C(C(NCC2(C3=CC=C(OC)C=C3)CCOCC2)=O)C=C1)=O
JW-55價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2026/07/06 | 46785 | JW55, 95% JW55, 95% | 664993-53-7 | 100mg | 6081元 |
| 2026/07/06 | S6745 | JW-55 JW55 | 664993-53-7 | 5mg | 795.22元 |
| 2026/07/06 | S6745 | JW-55 JW55 | 664993-53-7 | 25mg | 2432.49元 |
常見問題列表
生物活性
JW55是一種有效的、選擇性經(jīng)典Wnt信號通路抑制劑，通過抑制TNKS1/2的PARP區(qū)域發(fā)揮作用。靶點(diǎn)
| Target | Value |
|
Wnt
() |
體外研究
JW 55 (JW55) is a potent and selective inhibitor of the canonical Wnt pathway. Wnt3a-induced HEK293 cells containing a transiently transfected ST-Luc (SuperTop-luciferase) reporter show inhibition by JW55 with an IC 50 value of 470 nM. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells.
體內(nèi)研究
JW 55 (100 mg/kg, orally) reduces tumor development in conditional Apc knockout mice. JW55 reduces XWnt8-induced axis duplication in Xenopus embryos and Tamoxifen-induced polyposis formation in conditional APC mutant mice.