66969-81-1
66969-81-1 結(jié)構(gòu)式
基本信息
中文別名
硫大唑嗪硫達(dá)唑嗪
英文別名
BL-5111Tiodazosin
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[[5-(methylthio)-1,3,4-oxadiazol-2-yl]carbonyl]piperazine
Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl][5-(methylthio)-1,3,4-oxadiazol-2-yl]-
物理化學(xué)性質(zhì)
沸點(diǎn)690.2±65.0 °C(Predicted)
密度1.50±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)6.52±0.50(Predicted)
常見問(wèn)題列表
生物活性
Tiodazosin 是一種有效且有競(jìng)爭(zhēng)性的突觸后 α 腎上腺素能受體 (alpha adrenergic receptor) 拮抗劑。靶點(diǎn)
alpha adrenergic receptor
體外研究
Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist. In the mesenteric artery, Tiodazosin produces a parallel shift to the right in the concentration response curves to norepinephrine. A Schild plot constructed from two concentrations of Tiodazosin results in a pA 2 value of 8.66 and a slope equal to -0.99. Tiodazosin inhibits contraction to norepinephrine in the portal vein and the inhibition results in a nonparallel inhibition of the norepinephrine concentration-response curve with a marked depression of maximal norepinephrine response.