67-92-5

中文名稱(chēng) 鹽酸雙環(huán)維林

英文名稱(chēng) DICYCLOMINE HYDROCHLORIDE

CAS 67-92-5

分子式 C19H36ClNO2

分子量 345.95

MOL 文件 67-92-5.mol

更新日期 2024/03/22 17:31:02

67-92-5 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息鹽酸雙環(huán)維林價(jià)格(試劑級(jí)) 常見(jiàn)問(wèn)題列表

基本信息

中文別名

鹽酸雙環(huán)胺
鹽酸雙環(huán)維林

英文別名

atumin
dyspas
Bentyl)
mamiesan
oxityl-p
bentomine
merbentyl
Magesan P
procyclomin
di-syntramine

所屬類(lèi)別

分析化學(xué)：藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品

物理化學(xué)性質(zhì)

熔點(diǎn)164-166°C

儲(chǔ)存條件-20°C冷凍

溶解度H₂O: 50 mg/mL

形態(tài)powder

顏色off-white

水溶解性H2O: 50mg/mL

BCS Class2/4

InChI1S/C19H35NO2.ClH/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17;/h17H,3-16H2,1-2H3;1H

InChIKeyGUBNMFJOJGDCEL-UHFFFAOYSA-N

SMILESCCN(CCOC(C1(C2CCCCC2)CCCCC1)=O)CC.[Cl]

EPA化學(xué)物質(zhì)信息2-Diethylaminoethyl bicyclohexyl-1-carboxylate hydrochloride (67-92-5)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險(xiǎn)性描述H302-H315-H319-H335

防范說(shuō)明P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

危險(xiǎn)品標(biāo)志Xn

危險(xiǎn)類(lèi)別碼22-36/37/38

安全說(shuō)明26-36

WGK Germany3

RTECS號(hào)DT7350000

TSCATSCA listed

海關(guān)編碼2922199695

存儲(chǔ)類(lèi)別11 - Combustible Solids

危險(xiǎn)性類(lèi)別Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

毒性LD50 orl-rat: 1290 mg/kg DRUGAY 6,317,82

圖譜信息

鹽酸雙環(huán)維林(67-92-5)質(zhì)譜(MS)
鹽酸雙環(huán)維林(67-92-5)核磁圖(¹HNMR)
鹽酸雙環(huán)維林(67-92-5)核磁圖(¹³CNMR)
鹽酸雙環(huán)維林(67-92-5)紅外圖譜(IR1)
鹽酸雙環(huán)維林(67-92-5)紅外圖譜(IR2)

鹽酸雙環(huán)維林價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱(chēng)	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-B1339R	鹽酸雙環(huán)維林 Dicyclomine hydrochloride (Standard)	67-92-5	10 mg	300元
2026/06/05	HY-B1339R	鹽酸雙環(huán)維林 Dicyclomine hydrochloride (Standard)	67-92-5	25 mg	530元
2026/06/05	HY-B1339R	鹽酸雙環(huán)維林 Dicyclomine hydrochloride (Standard)	67-92-5	50 mg	800元

常見(jiàn)問(wèn)題列表

生物活性

Dicyclomine hydrochloride 是一種有效的口服活性毒蕈堿膽堿能受體 (muscarinic cholinergic receptors) 拮抗劑。Dicyclomine hydrochloride 對(duì) M1 受體亞型 (Ki=5.1 nM) 和 M2 受體亞型 (Ki=54.6 nM) 在刷緣膜和基底質(zhì)膜中均表現(xiàn)出較高的親和力。Dicyclomine hydrochloride是一種抗痙攣試劑，在體內(nèi)可緩解胃腸道平滑肌痙攣。

靶點(diǎn)

Ki: 5.1 nM (muscarinic M1 receptor subtype in brush-border membrane)Ki: 54.6 nM (muscarinic M2 receptor subtype in basal plasma membrane

體內(nèi)研究

Dicyclomine hydrochloride (intraperitoneal?injection; 8 mg/kg; daily) exacerbates the cognitive impairments in all the measurements. In addition, the memory impairments are worse in dicyclomine-treated 3xTg-AD mice compared to dicyclomine-treated NonTg mice.Dicyclomine hydrochloride (intraperitoneal injection; 2.0, 4.0, and 8.0 mg/kg; 7 days) produces a highly significant effect on performance in the paired-associates learning (PAL) task in mice.And systemic treatment at lower doses show behavioral impairments in mice in spatial tasks.

Animal Model:	C57Bl/6 mice
Dosage:	2.0, 4.0, and 8.0 mg/kg
Administration:	Intraperitoneal injection; daily; 7 days
Result:	Produced impairments due to actions of the agent outside of the hippocampus.