68003-38-3

中文名稱 2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸

英文名稱 2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid

CAS 68003-38-3

分子式 C13H9ClN2O6S

分子量 356.74

MOL 文件 68003-38-3.mol

更新日期 2026/06/02 12:03:25

68003-38-3 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸價格(試劑級) 常見問題列表

基本信息

中文別名

化合物CTPI-2
2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸

英文別名

Einecs 268-121-3
SLC25A1 inhibitor CTPI-2
2-(4'-Chloro-3'-nitrobenzenesulfonamido)benzoic acid
2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid
Benzoic acid, 2-(((4-chloro-3-nitrophenyl)sulfonyl)amino)-
2-(4-Chloro-3-nitrophenylsulfonylamino)benzenecarboxylic acid
macrophage,carrier,CTPI-2,NSCLC,transporter,glucose,steatohepatitis,CTPI 2,Mitochondrial Metabolism,steatosis,inflammatory,inhibit,citrate,Inhibitor,mitochondrial,CTPI2

物理化學(xué)性質(zhì)

沸點564.8±60.0 °C(Predicted)

密度1.660±0.06 g/cm3(Predicted)

儲存條件-20°C儲存

溶解度DMSO:125 mg/mL(350.40 mM)

酸度系數(shù)(pKa)3.19±0.36(Predicted)

形態(tài)固體

顏色Off-white to light yellow

InChI1S/C13H9ClN2O6S/c14-10-6-5-8(7-12(10)16(19)20)23(21,22)15-11-4-2-1-3-9(11)13(17)18/h1-7,15H,(H,17,18)

InChIKeyNJTHPOSQGFJTDP-UHFFFAOYSA-N

SMILES[S](=O)(=O)(Nc2c(cccc2)C(=O)O)c1cc(c(cc1)Cl)[N+](=O)[O-]

EPA化學(xué)物質(zhì)信息Benzoic acid, 2-[[(4-chloro-3-nitrophenyl)sulfonyl]amino]- (68003-38-3)

安全數(shù)據(jù)

危險性符號(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險性描述H302-H312-H315-H319-H332-H335

防范說明P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

WGK GermanyWGK 3

TSCATSCA listed

存儲類別11 - Combustible Solids

圖譜信息

2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸(68003-38-3)核磁圖(¹HNMR)

2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-123986	2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸 CTPI-2	68003-38-3	25 mg	415元
2026/06/05	HY-123986	2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸 CTPI-2	68003-38-3	10 mM * 1 mL in DMSO	456元
2026/06/05	HY-123986	2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸 CTPI-2	68003-38-3	50 mg	584元

常見問題列表

生物活性

CTPI-2 是一種線粒體檸檬酸鹽載體 SLC25A1 的抑制劑，KD值為3.5 μM。CTPI-2 是 glycolysis 的獨(dú)特調(diào)節(jié)劑，它限制了癌癥干細(xì)胞(CSCs)的代謝可塑性。

靶點

Target	Value
glycolysis ()
SLC25A1 (Cell-free assay)	3.5 μM(Kd)

體內(nèi)研究

CTPI-2 is a unique regulator of glycolysis that limits the metabolic plasticity of cancer stem cells (CSCs). CTPI-2 (26?mg/kg; i.p.) inhibits tumor growth in in vivo models of non-small cell lung cancer (NSCLC).
CTPI-2 (50 mg/kg; i.p.; alternate days for 12 weeks) completely averts weight gain in the prevention study and leads to significant weight loss in the reversion study.
CTPI-2 prevents steatohepatitis and normalizes glucose tolerance. CTPI-2 lowers the levels of circulating IL-6 while increasing anti-inflammatory IL-4 and IL-10 and also reduced the monocyte chemoattractant protein-1 and monokine-induced by interferon-γ that attract neutrophils and monocytes. CTPI-2 regulates the citrate pool, the lipogenic and the gluconeogenic pathways.

Animal Model:	C57BL/6J mice (HFD-fed mice)
Dosage:	50 mg/kg
Administration:	Alternate days via the intraperitoneal route for 12 weeks
Result:	Completely averted weight gain in the prevention study and led to significant weight loss in the reversion study.