68414-18-6

中文名稱腺苷5'-二磷酸核糖鈉

英文名稱 ADENOSINE 5'-DIPHOSPHORIBOSE SODIUM SALT

CAS 68414-18-6

分子式 C15H22N5NaO14P2

分子量 581.3

MOL 文件 68414-18-6.mol

更新日期 2026/04/25 14:55:25

68414-18-6 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息腺苷5'-二磷酸核糖鈉價(jià)格(試劑級) 常見問題列表

基本信息

中文別名

二磷酸腺苷核糖
腺苷5'-二磷酸核糖鈉

英文別名

adp-ribose
ADP ribose sodium
adenosine 5'-diphosphoribose sodium
ADENOSINE 5'-DIPHOSPHORIBOSE SODIUM SALT
Adenosine 5'-diphosphoribose sodium salt >=93%
ADENOSINE-5'-DIPHOSPHORIBOSE SODIUM SALT DIHYDRATE
ADENOSINE-5'-DIPHOSPHORIBOSE SODIUM SALT 2-HYDRATE
[[5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXYOXOLAN-2-YL]METHOXY-HYDROXYPHOSPHORYL] (2,3,4-TRIHYDROXY-5-OXOPENTYL) HYDROGEN PHOSPHATE,SODIUM

所屬類別

有機(jī)原料：羧酸類化合物及衍生物

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C

溶解度water: 50 mg/mL, clear, colorless

形態(tài)Solid

顏色White to light yellow

生物來源yeast (candida utilis)

水溶解性Water : 125 mg/mL (215.04 mM)

InChIKeyMBPRZUBFEMLFGQ-UUIVKEFHSA-M

SMILESO[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)C=O)O[C@H]1N1C=NC2C(=NC=NC1=2)N)O.[NaH] |&1:1,2,3,15,17,19,24,r|

安全數(shù)據(jù)

危險(xiǎn)性符號(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險(xiǎn)性描述H315-H319-H335

防范說明P261-P264-P271-P280-P302+P352-P305+P351+P338

危險(xiǎn)品標(biāo)志Xi

危險(xiǎn)類別碼36/37/38

安全說明26-36

WGK Germany3

存儲(chǔ)類別11 - Combustible Solids

危險(xiǎn)性類別Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

圖譜信息

腺苷5'-二磷酸核糖鈉(68414-18-6)核磁圖(¹HNMR)

腺苷5'-二磷酸核糖鈉價(jià)格(試劑級)

報(bào)價(jià)日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價(jià)格
2026/06/05	HY-100973AR	腺苷5'-二磷酸核糖鈉 Adenosine 5′-diphosphoribose sodium (Standard)	68414-18-6	5 mg	1500元
2026/06/05	HY-100973AR	腺苷5'-二磷酸核糖鈉 Adenosine 5′-diphosphoribose sodium (Standard)	68414-18-6	10 mg	2250元
2026/06/05	HY-100973AR	腺苷5'-二磷酸核糖鈉 Adenosine 5′-diphosphoribose sodium (Standard)	68414-18-6	25 mg	4000元

常見問題列表

生物活性

Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) 是一種煙酰胺腺嘌呤核苷酸 (NAD+) 的代謝產(chǎn)物，也是一種最有效和最主要的細(xì)胞內(nèi) Ca2+ 滲透性陽離子 TRPM2 通道激活劑，還可以增強(qiáng)自噬 (autophagy)。

靶點(diǎn)

TRPM2 channel
Autophagy

體外研究

In mouse embryonic fibroblasts (MEFs), H ₂ O ₂ treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca ²⁺ elevation through extracellular Ca ²⁺ influx and (or) lysosomal Ca ²⁺ release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress.
TRPM2 channels are activated by binding of Adenosine 5′-diphosphoribose (ADP ribose) to the intracellular NUDT9-homology (NUDT9-H) domain unique to TRPM2 and located at its C terminus. In addition to ADPR, intracellular Ca ²⁺ is an essential coactivator: TRPM2 channels open only in the combined presence of both ligands.