686772-17-8

中文名稱 CS-2394

英文名稱 IWP 4

CAS 686772-17-8

分子式 C23H20N4O3S3

分子量 496.62

MOL 文件 686772-17-8.mol

更新日期 2026/07/27 12:22:47

686772-17-8 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 CS-2394價格(試劑級) 常見問題列表

基本信息

中文別名

化合物IWP 4
2-((3-(2-甲氧基苯基)-4-氧代-3,4,6,7-四氫噻吩并[3,2-D]嘧啶-2-基)硫代)-N-(6-甲基苯并[D]噻唑-2-基)乙酰胺

英文別名

IWP 4
CS-2394
IWP4
IWP 4
IWP-4 >=95% (HPLC)
Wnt Inhibitor IWP-4
Inhibitor of Wnt Production-4
N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Acetamide, N-(6-methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-
2-((3-(2-methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide

所屬類別

生物化工：激動劑抑制劑

物理化學(xué)性質(zhì)

密度1.51±0.1 g/cm3(Predicted)

儲存條件-20°C

溶解度insoluble in H2O; insoluble in EtOH; insoluble in DMSO

酸度系數(shù)(pKa)9.01±0.70(Predicted)

形態(tài)粉末

顏色白色至淺棕色

InChI1S/C23H20N4O3S3/c1-13-7-8-14-18(11-13)33-22(24-14)26-19(28)12-32-23-25-15-9-10-31-20(15)21(29)27(23)16-5-3-4-6-17(16)30-2/h3-8,11H,9-10,12H2,1-2H3,(H,24,26,28)

InChIKeyRHUJMHOIQBDFQR-UHFFFAOYSA-N

SMILESO=C1C2=C(CCS2)N=C(SCC(NC3=NC(C=CC(C)=C4)=C4S3)=O)N1C5=C(OC)C=CC=C5

安全數(shù)據(jù)

危險性符號(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險性描述H302

防范說明P280-P305+P351+P338

WGK Germany3

存儲類別11 - Combustible Solids

危險性類別Acute Tox. 4 Oral

圖譜信息

CS-2394(686772-17-8)核磁圖(¹HNMR)

CS-2394價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-12879	IWP-4	686772-17-8	1 mg	411元
2026/06/05	HY-12879	CS-2394 IWP-4	686772-17-8	5mg	1500元
2026/06/05	HY-12879	CS-2394 IWP-4	686772-17-8	10mg	2500元

常見問題列表

生物活性

IWP-4 是一種小分子 Wnt 抑制劑，其 IC50 值為 25 nM。

靶點

IC50: 25 nM (Wnt)

體外研究

IWP-4 is a small molecule Wnt inhibitor with an IC ₅₀ of 25 nM. IWP-4 induces the expression of cardiac markers, including cardiac troponin I (CTNI) and cardiac myosin heavy chain bright cells (MYH ^{hi +} ). IWP-4 also results in the appearance of beating foci (0.44±0.10 SEM beats per second), which is absent in all cultures not receiving IWP-4. Further, flow cytometric analysis shows that there are significantly more MYH ^{lo +} cells in IWP-4 treated cultures (P<0.0002) compare with untreated cultures at day 16, being 17.0±1.3 SD% and 5.4±1.4 SD%, respectively. Quantification of NKX2-5 protein expression shows that 63% (481/817) of IWP-4 treated cells display nuclear NKX2-5 expression. Mesenchymal precursor cells (MPCs) treated with IWP-4 show no significant changes in the expression of AXIN2 , CTNNB1 and GSK3B as compare to osteogenic medium alone on day 7, but MPCs treated with IWP-4 express elevates levels of DKK1 and GSK3β on day 21. IWP-4 also causes a significant down regulation of SPARC and COL1A1 .