68890-66-4
68890-66-4 結(jié)構(gòu)式
基本信息
羥吡酮
1-羥基-4-甲基-6-(2,4,4-三甲苯基)吡啶酮乙醇胺復(fù)合鹽(1:1)
去屑劑
吡羅克酮 乙醇胺鹽
吡啶酮乙醇胺鹽(去屑劑OCTO)
1-羥基-4-甲基-6-(2,4,4-三甲苯基)吡啶酮乙醇胺復(fù)合鹽
OCTOPIROX
PIROCTONE OLAMINE
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1h)-pyridinoncompd.with2-aminoethanol(1:1)
2(1H)-Pyridinone,1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-,compd.with2-aminoethanol(1:1)
4,4-trimethylpentyl)-1-hydroxy-4-methyl-6-(compd.with2-2(1h)-pyridinon
octopiroxolamine
PIROCTONE OLEAMINE
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
Piroctone olamine (OCTO)
Piorctone Olamine
1-HYDROXY-4-METHYL-6-(2,4,4-TRIMETHYLPENTYL)2(1H)-PYRIDONE.
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-on, Verbindung mit 2-Aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone·2-aminoethanol
2-Aminoethanol/1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone,(1:1)
物理化學(xué)性質(zhì)
environmental
ANTI-SEBORRHEIC
安全數(shù)據(jù)
Eye Dam. 1
Skin Irrit. 2
常見(jiàn)問(wèn)題列表
吡羅克酮乙醇胺鹽獨(dú)特的性能主要表現(xiàn)在：
1. 去屑止癢效果優(yōu)于同類產(chǎn)品。
2. 溶解性能、復(fù)配性能優(yōu)良，與化妝品原料混合不會(huì)發(fā)生沉淀或分層現(xiàn)象。
3. 去屑機(jī)理獨(dú)特，刺激性極低，不會(huì)引起脫發(fā)、斷發(fā)，安全性優(yōu)于同類去屑止癢產(chǎn)品。
吡啶酮乙醇胺鹽是一種吡啶衍生物。具有殺真菌作用。
Antifungal
Piroctone olamine, the ethanolamine salt of the hydroxamic acid derivative Piroctone, is a hydroxypyridone anti-mycotic agent. Piroctone olamine penetrates the cell membrane and forms complexes with iron ions, inhibiting energy metabolism in mitochondria. Piroctone olamine (PO) is an ethanolamine salt of the hydroxamic acid derivative Piroctone. All Candida strains show low minimum inhibitory concentrations (MICs) for Piroctone olamine (0.125-0.5 μg/mL) and Amphotericin B (AMB) (0.03-1 μg/mL).
This work aimed to evaluate the antifungal activity of Piroctone olamine in the treatment of intra-abdominal candidiasis in an experimental model using Swiss mice. The treatment with Piroctone olamine (0.5 mg/kg) is performed 72 h after infection by intraperitoneal administration. For comparison, a group of animals (n=6) is treated with Amphotericin B (0.5 mg/kg). The mycological diagnosis is made by collecting the liver, spleen and kidneys. Data regarding the fungal growth and mortality are analyzed statistically by Student’s t test and analysis of variance, with level of significance set at P<0.05. The difference in fungal growth scoring between the control group and the treatment groups (Piroctone olamine and Amphotericin B) is statistically significant (P<0.05).