69-25-0

中文名稱依來多辛

英文名稱 Eledoisin

CAS 69-25-0

分子式 C54H85N13O15S

分子量 1188.4

MOL 文件 69-25-0.mol

更新日期 2026/05/29 13:07:22

69-25-0 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 常見問題列表依來多辛價格(試劑級)

基本信息

中文別名

麝香蛸素
依來多辛
醋酸依來多辛
醋酸依來多辛 69-25-0
醋酸依來多辛 ELEDOISINACETATE

英文別名

ELEDOSIN
ELEDOISIN
eledonepeptide
Eledosin Acetate
Eledoisin Acetate
PYR-PSKDAFIGLM-NH2
GLP-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2
PYR-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2
PGLU-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2
5-Oxo-L-Pro-L-Pro-L-Ser-L-Lys-L-Asp-L-Ala-L-Phe-L-Ile-Gly-L-Leu-L-Met-NH2

所屬類別

生物化工：多肽

物理化學(xué)性質(zhì)

熔點230 °C (decomp)

沸點1618.1±65.0 °C(Predicted)

密度1.289±0.06 g/cm3(Predicted)

儲存條件−20°C

溶解度DMF: 15 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:20): 0.04 mg/ml

酸度系數(shù)(pKa)4.19±0.10(Predicted)

形態(tài)結(jié)晶固體

顏色White to off-white

旋光度 (Optical Rotation)-4422 (95% Acetic Acid)

序列{Glp}-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2

安全數(shù)據(jù)

WGK Germany3

RTECS號JX8688000

海關(guān)編碼3504009000

常見問題列表

用途

依來多辛是 NK2 和 NK3 受體的特異性激動劑。

靶點

NK2 and NK3 receptors.

體外研究

Eledoisin (Eledone peptide) increases the value recorded under basal conditions by 24.5±3.7%; this stimulation is significantly (P<0.01) lowered to 13.1±1.9% by the simultaneous presence of CP99994. The same protocol is also used to characterize the sensitivity of Eledoisin stimulation to 0.1 μM SR48968 or 0.1 μM SB222200. SR48968 significantly (P < 0.01) lower the stimulation by Eledoisin, while SB222200 has no effect. Eledoisin stimulation is reduced by CP99994 and SR48968, NK1 and NK2 antagonists, respectively.

體內(nèi)研究

Eledoisin (Eledone peptide; 0.1-1 nmol/kg) injected into rats produces a biphasic cardiovascular response that consists of an initial fall of systemic blood pressure (8-15 mm Hg) followed by a rise (20-22 mm Hg). Intracerebroventricular injection of Eledoisin produces an enhancement of grooming and scratching behavior in mice.

依來多辛價格(試劑級)