6953-61-3
6953-61-3 結(jié)構(gòu)式
基本信息
Naphthohydroxamicacid
a-Naphthohydroxamic acid
1-NAPHTHOHYDROXAMIC ACID
alpha-naphthohydroxamicacid
1-NAPHTHOHYDROXAMIC ACID 98+%
HDAC Inhibitor XIX, Compound 2
1-Naphthalenecarbohydroximic acid
n-hydroxy-1-naphthalenecarboxamid
N-Hydroxy-1-naphthalenecarboxamide
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/06 | N0023 | 1-萘羥肟酸 1-Naphthohydroxamic Acid | 6953-61-3 | 1G | 1700元 |
| 2026/06/05 | HY-130538 | 1-萘羥肟酸 1-Naphthohydroxamic acid | 6953-61-3 | 1 mg | 175元 |
| 2026/06/05 | HY-130538 | 1-萘羥肟酸 1-Naphthohydroxamic acid | 6953-61-3 | 5mg | 404元 |
常見問題列表
|
HDAC8 14 μM (IC 50 ) |
HDAC1 >100 μM (IC 50 ) |
HDAC6 >100 μM (IC 50 ) |
1-Naphthohydroxamic acid (compound 2; 20-40 μM; 0-144 ?hours; BE(2)-C, SK-N-BE(2) and SH-SY5Y cells) treatment reduces cell numbers in a concentration-dependent manner.
1-Naphthohydroxamic acid (compound 2) at concentrations in the range of its in vitro IC
50
against HDAC8 results in reduced cell density and outgrowth of neurite-like structures that stained positive for neurofilament.1-Naphthohydroxamic acid reduces the formation of clones in soft-agar concentration dependently.
When either cell type (HeLa and HEK293 cells) is treated with 1-Naphthohydroxamic acid (compound 2; 0.8 μM, 4 μM, 20 μM or 100 μM), only tubulin becomes hyperacetylated.
Cell Proliferation Assay
| Cell Line: | BE(2)-C, SK-N-BE(2) and SH-SY5Y cells |
| Concentration: | 20 μM, 40 μM |
| Incubation Time: | 0?hours, 24?hours, 48?hours, 72?hours, 96?hours, and 144 ?hours |
| Result: | Reduced cell numbers in a concentration-dependent manner. |
Dose-limiting toxicities (DLTs) of 1-Naphthohydroxamic acid (compound 2; 0-40 mg/kg; intraperitoneal injection; daily; for 10 day; NMRI
Foxn1
nude mice) include weight loss and signs of liver toxicity, as evidenced by elevated plasma liver enzymes and detection of necrotic areas on histological liver examination. 1-Naphthohydroxamic acid has the maximum tolerable doses at 50?mg/kg per day. At these concentrations, neither body weight nor blood parameters are critically changed.
Pharmacokinetic studies after intraperitoneal administration of the inhibitors identified the half-life of 1-Naphthohydroxamic acid to be ~15?min, with a plasma peak concentration of ~30?μM.
| Animal Model: | NMRI Foxn1 nude mice |
| Dosage: | 0 mg/kg, 50 mg/kg, 100mg/kg, 200 mg/kg, 300 mg/kg 400 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 10 days |
| Result: | Dose-limiting toxicities (DLTs) included weight loss and signs of liver toxicity, as evidenced by elevated plasma liver enzymes and detection of necrotic areas on histological liver examination. |