70775-75-6
70775-75-6 結(jié)構(gòu)式
基本信息
鹽酸奧替尼啶
奧替尼啶雜質(zhì)
奧替尼啶鹽酸鹽
奧克太啶鹽酸鹽
奧替尼定鹽酸鹽
奧替尼啶雙鹽酸鹽
奧替尼啶 二鹽酸鹽
奧替尼啶,奧克太啶
奧替尼啶,奧克太啶鹽酸鹽
SOT360
Octenidine DiHCl
Otinidine hydrochloride
ocenidine dihydrochloride
OCTENIDINE DIHYDROCHLORIDE
Ortinidine dihydrochloride
TRANS-2-NONENAL 18829-56-6
OctenidineDihydrochloride>
Octenidine dihydrochloride 97%
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
2162-98-3
64690-19-3
70775-75-6
以1,10-二氯癸烷和4-(辛基氨基)吡啶為原料，合成N,N'-[1,10-亞癸基二-1(4H)-吡啶-4-亞基]雙(1-辛胺)二鹽酸鹽的一般步驟如下：將6.18 g的4-(辛基氨基)吡啶堿和3.15 g的1,10-二氯癸烷混合，緩慢加熱至120℃，反應(yīng)放熱至180℃，期間通過(guò)薄層色譜（TLC）監(jiān)測(cè)反應(yīng)進(jìn)程。反應(yīng)完成后，加入25 mL二甲基甲酰胺（DMF），加熱使混合物完全溶解。隨后，將混合物冷卻至0℃以促進(jìn)晶體析出，過(guò)濾收集晶體，并在60℃下減壓干燥。通過(guò)上述步驟，獲得7.3 g的N,N'-[1,10-亞癸基二-1(4H)-吡啶-4-亞基]雙(1-辛胺)二鹽酸鹽，產(chǎn)率為39.0%，熔點(diǎn)為215至217℃。
參考文獻(xiàn)：
[1] Patent: KR2017/13425, 2017, A. Location in patent: Paragraph 0105; 0106
[2] Patent: US2001/16660, 2001, A1
[3] Patent: US2001/16660, 2001, A1
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/07/06 | H62257 | 奧替尼啶 二鹽酸鹽, 98% Octenidine dihydrochloride, 98% | 70775-75-6 | 1g | 207元 |
| 2026/07/06 | S5012 | 奧替尼啶鹽酸鹽 Octenidine Dihydrochloride | 70775-75-6 | 25mg | 795.23元 |
| 2026/06/06 | O0388 | 奧替尼啶二鹽酸鹽 Octenidine Dihydrochloride | 70775-75-6 | 1g | 60元 |
常見(jiàn)問(wèn)題列表
Octenidine concentrations of less than1.5 μM (0.94 μg/mL) causes a greater than 99% reduction of tested microbial population within 15 min. Staphylococcus epidermidis is the most susceptible of the test organisms, and E. coli and C. albicans are the least susceptible.
The antimicrobial activity of octenidine hydrochloride (OCT) is maintained when applied to the skin of the hands and feet of cynomolgus monkeys. Aqueous octenidine, at a concentration of 0.2 to 1.6% reduces resident microflora populations from 90 to 99.98%. A significant reduction in plaque score is observed on the buccal tooth surfaces after daily topical application of 1% solutions of octenidine and chlorhexidine for 7 d; octenidine is more effective than chlorhexidine.