72803-02-2
中文名稱
達(dá)羅地平
英文名稱
Darodipine
CAS
72803-02-2
分子式
C19H21N3O5
分子量
371.39
MOL 文件
72803-02-2.mol
更新日期
2023/02/09 13:42:07
72803-02-2 結(jié)構(gòu)式
基本信息
中文別名
達(dá)羅地平 英文別名
PY-108068PY-108063
PY-108-068
Darodipine
Darodipine(PY-108068)
4-(Benzofurazan-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester
3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
所屬類別
生物化工：生化試劑物理化學(xué)性質(zhì)
熔點(diǎn)148-151°C
儲(chǔ)存條件Refrigerator
溶解度可溶于氯仿（少許）、DMSO（少許）、甲醇（少許）
形態(tài)固體
顏色淡黃色至淡黃色
InChIInChI=1S/C19H21N3O5/c1-5-25-18(23)14-10(3)20-11(4)15(19(24)26-6-2)16(14)12-8-7-9-13-17(12)22-27-21-13/h7-9,16,20H,5-6H2,1-4H3
InChIKeyQERUYFVNIOLCHV-UHFFFAOYSA-N
SMILESC1(C)NC(C)=C(C(OCC)=O)C(C2C3C(C=CC=2)=NON=3)C=1C(OCC)=O
達(dá)羅地平價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-U00086 | 達(dá)羅地平 Darodipine | 72803-02-2 | 2 mg | 1142元 |
常見(jiàn)問(wèn)題列表
生物活性
Darodipine (PY 108-068, PY-108068) 是有效地鈣離子通道 (calcium chanel) 拮抗劑。體內(nèi)研究
Treatment with darodipine increases the number and the average length of alkaline phosphatase-reactive capillaries and reduces the intercapillary distance and the diameter of cerebral capillaries in old rats. The pericapillary microrenvironment of the Ammon’s horn is the most sensitive to treatment with darodipine. Darodipine may reduce neuronal cytoskeletal changes occurring in aging and in neurodegenerative disorders. A 6-month treatment (from the 18th to the 24th month of life) with an oral daily dose of 10 mg/kg of darodipine restores in part the expression of 200 kDa-NF subunit immunoreactivity in the cerebellar cortex.