72873-74-6

中文名稱 6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氫咪唑并[2,1-B]-噻唑

英文名稱 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE

CAS 72873-74-6

分子式 C16H12FN3S

分子量 297.35

MOL 文件 72873-74-6.mol

更新日期 2023/10/26 17:11:16

72873-74-6 結構式

基本信息物理化學性質(zhì) 安全數(shù)據(jù) 圖譜信息 6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氫咪唑并[2,1-B]-噻唑價格(試劑級) 常見問題列表

基本信息

中文別名

6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氫咪唑并[2,1-B]-噻唑

英文別名

CS-1711
SKF-86002
SKF 86002
SKF86002
SKF 86002 DIHYDROCHLORIDE
SKF-86002 - CAS 72873-74-6 - Calbiochem
6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroiMidazo[2,1-b]thi
5-(4-Pyridyl)-6-(4-fluorophenyl)-2,3-dihydroimidazo[2,1-b]thiazole
6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDYL)IMIDAZO[2,1-B]THIAZOLE
6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PRIDYL)IMIDAZO-[2,1,B]-THAIZOLE
6-(4-FLUOROPHENYL)-5-(4-PYRIDYL)-2,3-DIHYDROIMIDAZO[2,1-B]-THIAZOLE

所屬類別

生物化工：激動劑抑制劑

物理化學性質(zhì)

熔點189-190 °C(lit.)

沸點476.1±55.0 °C(Predicted)

密度1.39±0.1 g/cm3(Predicted)

儲存條件Keep in dark place,Sealed in dry,2-8°C

溶解度DMSO: 9 mg/mL, soluble

酸度系數(shù)(pKa)4.36±0.10(Predicted)

形態(tài)solid

顏色off-white

InChIInChI=1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2

InChIKeyYOELZIQOLWZLQC-UHFFFAOYSA-N

SMILESS1CCN2C(C3C=CN=CC=3)=C(C3=CC=C(F)C=C3)N=C12

安全數(shù)據(jù)

危險性符號(GHS) 有毒 (GHS06)

GHS06

警示詞危險

危險性描述H301+H311+H331-H315-H319-H227

防范說明P501-P261-P270-P210-P271-P264-P280-P370+P378-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P403+P235-P405

危險品標志Xi

危險類別碼36/37/38

安全說明26-36

WGK Germany3

海關編碼2934999090

圖譜信息

6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氫咪唑并[2,1-B]-噻唑(72873-74-6)核磁圖(¹HNMR)

6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氫咪唑并[2,1-B]-噻唑價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-12511R	6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氫咪唑并[2,1-B]-噻唑 SKF-86002 (Standard)	72873-74-6	5 mg	1200元
2026/06/05	HY-12511R	6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氫咪唑并[2,1-B]-噻唑 SKF-86002 (Standard)	72873-74-6	10 mg	1800元
2026/06/05	HY-12511R	6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氫咪唑并[2,1-B]-噻唑 SKF-86002 (Standard)	72873-74-6	25 mg	3240元

常見問題列表

生物活性

SKF-86002 是一種具有口服活性的 p38 MAPK 抑制劑，具有抗炎、抗關節(jié)炎和鎮(zhèn)痛活性。SKF-86002 能抑制脂氧合酶和環(huán)氧合酶介導的花生四烯酸代謝。

體外研究

SKF-86002 (10 μM; 1 hour) inhibits apoptosis induced by stress stimulation with UV irradiation (UV).
SKF-86002 does not inhibit UV-induced apoptosis in undifferentiated HL-60 cells.
SKF-86002 (10 μM; 72 hours) prevent IL-4-induced monocyte or U937 cell CD23 surface expression and protein formation with no effect on CD23 mRNA levels.

Western Blot Analysis

Cell Line:	U937 cells
Concentration:	10 μM
Incubation Time:	72 hours
Result:	Significantly reduced CD23 levels on IL-4-treated U937 cells.

體內(nèi)研究

SKF-86002 (10-90 mg/kg; p.o.; daily; for 22 days) has antiarthritic activity.

Animal Model:	Lewis rats, with adjuvant-induced arthritis (AA)
Dosage:	10 mg/kg, 30 mg/kg, 90 mg/kg
Administration:	Oral administration, daily, for 22 days
Result:	Significantly decreased hindleg volumes after injection of adjuvant.