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75899-68-2

中文名稱 4-羥基壬烯醛
英文名稱 HNE
CAS 75899-68-2
分子式 C9H16O2
MDL 編號 MFCD00211020
分子量 156.22
MOL 文件 75899-68-2.mol
更新日期 2026/05/28 12:19:25
75899-68-2 結構式 75899-68-2 結構式

基本信息

中文別名
4-羥基壬烯醛
(E)-4-羥基-2-壬烯醛
英文別名
HNE
所屬類別
有機原料:醛類化合物

物理化學性質

沸點125-127 °C(Press: 2 Torr)
密度0.941±0.06 g/cm3(Predicted)
儲存條件-70°C
溶解度DMF: >50 mg/ml; DMSO: >50 mg/ml; Ethanol: >50 mg/ml; PBS pH 7.2: >1 mg/ml
酸度系數(shù)(pKa)13.31±0.20(Predicted)
形態(tài)無色油狀物。
顏色Colorless to light yellow
InChIInChI=1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3/b7-5+
InChIKeyJVJFIQYAHPMBBX-FNORWQNLSA-N
SMILESC(=O)/C=C/C(O)CCCCC

安全數(shù)據

危險性符號(GHS)易燃 (GHS02)有害 (GHS07)
GHS02,GHS07
警示詞危險
危險性描述H225-H319
4-羥基壬烯醛價格(試劑級)
報價日期產品編號產品名稱CAS號包裝價格
2026/06/05HY-113466R4-羥基壬烯醛
4-Hydroxynonenal (Standard)
75899-68-21 mg1500元
2026/06/05HY-113466R4-羥基壬烯醛
4-Hydroxynonenal (Standard)
75899-68-25 mg3000元
2026/06/05HY-1134664-羥基壬烯醛
4-Hydroxynonenal
75899-68-21 mg480元

常見問題列表

生物活性
4-Hydroxynonenal (4-HNE) 是一種 α,β 不飽和羥基烯醛,是一種氧化/亞硝化應激生物標志物。4-Hydroxynonenalal 是 ALDH2 的底物和抑制劑。4-Hydroxynonenalal 可以調節(jié)許多信號傳導過程,主要是通過與蛋白質,核酸和膜脂質中具有親核官能團的共價加合物形成的。4-Hydroxynonenalal 通過線粒體在癌癥中起重要作用。
靶點

Human Endogenous Metabolite

體外研究

4-Hydroxynonenal is both a substrate and an inhibitor of ALDH2; inhibition of ALDH2 by 4-Hydroxynonenal is reversible at low concentration and become irreversible when the concentration of 4-HNE reaches 10 μM.
4-Hydroxynonenal can induce antioxidant defense mechanisms to restrain its own production and to enhance the cellular protection against oxidative stress.
4-Hydroxynonenal, the product of lipid peroxidation, is mutagenic and genotoxic in viruses, bacteria and mammalian cells. It reacts with all four DNA bases but with different efficiency: G >C > A >T. 4-Hydroxynonenal-dG represents the best biomarker of the genotoxic effects of 4-Hydroxynonenal and these adducts are primarily found in nuclear DNA. A classic example of etiological relevance of 4-Hydroxynonenal-dG in human cancers is 4-Hydroxynonenal-dG induced p53 mutation. 4-Hydroxynonenal-dG adducts were preferentially formed at the third base of codon 249 in the p53 gene, causing gene mutation and affecting diverse biological processes including cell cycle arrest, apoptosis, DNA repair, and differentiation.

體內研究

Following 24 h after fluid percussion injury (FPI), the mouse brain tissue is analyzed for the expression level of NADPH oxidase 1 (NOX1), inducible nitric oxide synthase (iNOS), 4-Hydroxynonenal (4-HNE. Both wild-type (Nrf2 +/+ ) and Nrf2-deficient mice (Nrf2 ?/? ) results in increased expression of 4-Hydroxynonenal following 15 psi injury (moderate injury) when compared to uninjured Nrf2 +/+ and Nrf2 ?/? mice. Similar to iNOS result, in Nrf2 ?/? KO mice, the expression level of 4-Hydroxynonenal is significantly high when compared to corresponding injured and uninjured Nrf2 +/+ WT animals.

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