78416-81-6

中文名稱(chēng) 鹽酸曲林菌素

英文名稱(chēng) HL 725

CAS 78416-81-6

分子式 C24H28ClN3O3

分子量 441.95

MOL 文件 78416-81-6.mol

更新日期 2026/07/08 09:26:51

78416-81-6 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 常見(jiàn)問(wèn)題列表鹽酸曲林菌素價(jià)格(試劑級(jí))

基本信息

中文別名

曲喹辛
鹽酸曲林菌素

英文別名

HL 725
HL 725 HCL
TREQUINSIN
Trequinsin, HCl
TREQUINSIN HYDROCHLORIDE
DTCZZBVPTHVXFA-OSMRDGEFSA-N
TREQUINSIN HYDROCHLORIDE MINIMUM 98%
4,6-trimethylphenyl)imino)--2-((monohydrochloride
Trequinsin, Hydrochloride - CAS 78416-81-6 - Calbiochem
4h-pyrimido(6,1-a)isoquinolin-4-one,2,3,6,7-tetrahydro-9,10-dimethoxy-3-methyl

物理化學(xué)性質(zhì)

熔點(diǎn)210-211 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7))

儲(chǔ)存條件Desiccate at RT

溶解度DMSO: 100 mM; Ethanol: 100 mM

形態(tài)淡黃色固體

顏色Light yellow to yellow

水溶解性water: 500μM

InChI1S/C24H27N3O3.ClH/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4;/h9-13H,7-8H2,1-6H3;1H/b25-22+;

InChIKeyDTCZZBVPTHVXFA-OSMRDGEFSA-N

SMILESCl[H].COc1cc2CCN3C(=O)N(C)C(\C=C3c2cc1OC)=N\c4c(C)cc(C)cc4C

安全數(shù)據(jù)

WGK Germany3

RTECS號(hào)UW7727000

存儲(chǔ)類(lèi)別11 - Combustible Solids

常見(jiàn)問(wèn)題列表

用途

鹽酸曲林菌素具有心血管保護(hù)和降壓作用。

生物活性

Trequinsin hydrochloride (HL 725) 是高效的血小板 CAMP 磷酸二酯酶 (PDE)的抑制劑，IC50的0.25 nM。Trequinsin hydrochloride (HL 725) 是 ADP、膠原蛋白、凝血酶和腎上腺素在體外誘導(dǎo)的血小板聚集的極有效抑制劑。

體外研究

Trequinsin hydrochloride exerts besides its cardiovascular and antihypertensive qualities very potent antiplatelet activities.
Trequinsin hydrochloride is an efficacious agonist of [Ca ²⁺ ] _i .

Cell Viability Assay

Cell Line:	Samples from healthy volunteer research donors with normal sperm motility parameters in agreement with World Health Organization 2010 criteria.
Concentration:	10 μM.
Incubation Time:	20 min.
Result:	Caused a concentrationdependent increase in [Ca ²⁺ ] _i (EC ₅₀ = 6.4 μM [95% confidence interval (CI): 4.1-9.9 μM]).

鹽酸曲林菌素價(jià)格(試劑級(jí))